945652-35-7Relevant articles and documents
2-QUINOLONE DERIVED INHIBITORS OF BCL6
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Paragraph 00329, (2018/12/13)
The present invention relates to compounds of formula I that function as inhibitors of BCL6(B- cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer,as well as other diseases or conditions in which BCL6 activity is implicated.
CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY
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Page/Page column 30, (2016/09/26)
The present invention relates to carboxamide inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
Purine derivatives
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, (2008/06/13)
A compound of formula (I), or a pharmaceutically acceptable salt thereof: STR1 wherein X is hydrogen, amino, halogen, hydroxy, lower alkoxy or lower alkyl andR 1 is STR2 wherein Y is methylene or a valence bond, R 2 and R 5 is H or lower, straight or branched alkyl,R 3 is H or lower alkyl, orR 2 and R 3 can together form a cyclobutyl, cyclopentyl, cyclohexyl or phenyl ring,Z is oxygen, methylene, sulphur, sulphonyl or a valence bond,R 4 is H, lower alkyl, aralkyl, a mono or bicyclic aromatic system optionally substituted with various groups.The compounds have been found useful for treating central nervous system ailments.
2, N6 -disubstituted adenosines, tri-O-ester derivatives and their pharmaceutical compositions to treat ischemias
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, (2008/06/13)
A compound of formula (I), or a pharmaceutically acceptable salt thereof: STR1 wherein X is halogen, trifluoromethyl, cyano, C 1-6 -alkoxy, C 1-6 -alkylthio, C 1-6 -alkylamino or C 1-6 -dialkylamino;R 1 and R 4 are H or straight or branched C 1-6 -alkyl o