945988-45-4

Basic information

• Product Name: 2-Chloro-4-cyclohexyloxy-pyridine
• Synonyms: 2-Chloro-4-cyclohexyloxy-pyridine
• CAS NO: 945988-45-4
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• Mol File: 945988-45-4.mol

Chemical Properties

• Boiling Point: 317.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• PKA: 2.20±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-4-cyclohexyloxy-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-cyclohexyloxy-pyridine(945988-45-4)
• EPA Substance Registry System: 2-Chloro-4-cyclohexyloxy-pyridine(945988-45-4)

Safety Data

• Hazardous Substances Data: 945988-45-4(Hazardous Substances Data)

Upstream product

• 34941-91-8 2-chloro-4-fluoropyridine 
• 108-93-0 cyclohexanol 

Relevant articles and documents

Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)

ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysophosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/PI pathway in regulating (neuro)immunological functions in both the central nervous system and periphery. Selective inhibitors of ABHD12 would offer valuable pharmacological probes to complement genetic models of ABHD12-regulated (lyso)-PS/PI metabolism and signaling. Here, we provide a detailed description of the discovery and activity-based protein profiling (ABPP) guided optimization of reversible thiourea inhibitors of ABHD12 that culminated in the identification of DO264 as a potent, selective, and in vivo active ABHD12 inhibitor. We also show that DO264, but not a structurally related inactive control probe (S)-DO271, augments inflammatory cytokine production from human THP-1 macrophage cells. The in vitro and in vivo properties of DO264 designate this compound as a suitable chemical probe for studying the biological functions of ABHD12-(lyso)-PS/PI pathways.

GLUCOKINASE ACTIVATORS

Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase. (Formula I) wherein R2, L, Z, Y, G and R1 are as defined in the claims.