- HYDRAZONOPYRROLIDINE DERIVATIVES FOR USE IN PREVENTING AND/OR TREATING DISORDERS ASSOCIATED TO ACINETOBACTER BAUMANNII
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The present invention relates to compounds of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated to Acinetobacter baumannii. The present invention al
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Page/Page column 18; 43-44
(2020/09/08)
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- Simple and efficient approach for synthesis of hydrazones from carbonyl compounds and hydrazides catalyzed by meglumine
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A simple, environmentally benign protocol for synthesis of hydrazones from carbonyl compounds and hydrazides has been developed in the presence of meglumine in aqueous-ethanol media at room temperature. The salient features of the present protocol are mild reaction conditions, short reaction time, high yields, operational simplicity, metal-free, applicability toward large-scale synthesis, and biodegradable and inexpensive catalyst.
- Zhang, Mo,Shang, Ze-Ren,Li, Xiao-Tang,Zhang, Jia-Nan,Wang, Yong,Li, Kang,Li, Yang-Yang,Zhang, Zhan-Hui
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p. 178 - 187
(2017/01/10)
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- Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions
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A highly selective and efficient method for the synthesis of 5-trifluoromethylated and 5-perfluoroalkylated pyrazoles has been developed which relies on the cyclization of hydrazine dianions with ethyl perfluorocarboxylates. The pyrazoles prepared were ev
- Ngo, Thang Ngoc,Ejaz, Syeda Abida,Hung, Tran Quang,Dang, Tuan Thanh,Iqbal, Jamshed,Lecka, Joanna,Sévigny, Jean,Langer, Peter
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p. 8277 - 8290
(2015/08/03)
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- Development of solvent-free ambient mass spectrometry for green chemistry applications
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Green chemistry minimizes chemical process hazards in many ways, including eliminating traditional solvents or using alternative recyclable solvents such as ionic liquids. This concept is now adopted in this study for monitoring solvent-free reactions and analysis of ionic liquids, solids, and catalysts by mass spectrometry (MS), without using any solvent. In our approach, probe electrospray ionization (PESI), an ambient ionization method, was employed for this purpose. Neat viscous room-temperature ionic liquids (RTILs) in trace amounts (e.g., 25 nL) could be directly analyzed without sample carryover effect, thereby enabling high-throughput analysis. With the probe being heated, it can also ionize ionic solid compounds such as organometallic complexes as well as a variety of neat neutral solid chemicals (e.g., amines). More importantly, moisture-sensitive samples (e.g., [bmim][AlCl4]) can be successfully ionized. Furthermore, detection of organometallic catalysts (including air-sensitive [Rh-MeDuPHOS][OTf]) in ionic liquids, a traditionally challenging task due to strong ion suppression effect from ionic liquids, can be enabled using PESI. In addition, PESI can be an ideal approach for monitoring solvent-free reactions. Using PESI-MS, we successfully examined the alkylation of amines by alcohols, the conversion of pyrylium into pyridinium, and the condensation of aldehydes with indoles as well as air- and moisture-sensitive reactions such as the oxidation of ferrocene and the condensation of pyrazoles with borohydride. Interestingly, besides the expected reaction products, the reaction intermediates such as the monopyrazolylborate ion were also observed, providing insightful information for reaction mechanisms. We believe that the presented solvent-free PESI-MS method would impact the green chemistry field.
- Liu, Pengyuan,Forni, Amanda,Chen, Hao
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p. 4024 - 4032
(2014/05/06)
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- Oxidized single-walled carbon nanotubes (swcns-cooh) as a new catalyst for the protection of carbonyl groups as hydrazones
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Nano-materials are considered as suitable heterogeneous catalysts for many organic reactions. Herein oxidized carbon nanotube (SWCNTs-COOH) has been reported as a heterogeneous catalyst, for protection of carbonyl groups as hydrazones in EtOH at 80 C. The reactions proceed smoothly with good to excellent yields, and the SWCNTs-COOH used can be recycled.
- Borazjani, Maryam Kiani,Safaei, Hamid Reza,Panahandeh, Majid,Kiani, Ali Reza,Kiani, Masoumeh,Mofarahi, Masoud
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p. 279 - 281
(2013/12/04)
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- Efficient solvent-free synthesis of thiazolidin-4-ones from phenylhydrazine and 2,4-dinitrophenylhydrazine
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An efficient solvent-free synthesis of thiazolidinones from reaction of mercaptoacetic acid, aldehydes (benzaldehyde and valeraldehyde) or ketones (cyclopentanone and cyclohexanone), and hydrazines (phenylhydrazine and 2,4-dinitrophenylhydrazine) is reported. The compounds were generally characterized by spectroscopic techniques and specifically for 2-cyclohexanyl-3-(N-phenyl)-1,3-thiazolidin-4-one by X-ray crystallography.
- Neuenfeldt, Patrícia D.,Drawanz, Bruna B.,Siqueira, Geonir M.,Gomes, Claudia R.B.,Wardell, Solange M.S.V.,Flores, Alex F.C.,Cunico, Wilson
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supporting information; experimental part
p. 3106 - 3108
(2010/07/18)
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- VIRAL POLYMERASE INHIBITORS
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The present invention relates to viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV), processes for their preparation and their use in the treatment of infections.
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Page/Page column 76
(2009/01/20)
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- A new approach to difficult Fischer synthesis: The use of zinc chloride catalyst in triethylene glycol under controlled microwave irradiation
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Application of triethylene glycol with catalytic quantity of zinc chloride (ZnCl2/TEG) is described as a new and efficient reaction medium for a difficult Fischer synthesis, leading to sensitive indoles. Transformation of the 3-acetyl-1-methylthiocycloalka[c]pyridine phenylhydrazones and p-methoxyphenylhydrazones into the 2-(2-pyridyl)indoles and 5-methoxy-2-(2- pyridyl)indoles, which are the synthons in our total synthesis of the sempervirine-type alkaloids, is carried out under controlled microwave irradiation in dry zinc chloride solution (0.16 M) in TEG. This protocol produces indoles from acetophenone or cyclohexanone via their phenylhydrazones in excellent yields.
- Lipinska, Teodozja M.,Czarnocki, Stefan J.
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p. 367 - 370
(2007/10/03)
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- Dowex polymer-mediated protection of carbonyl groups
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Dowex (strongly acidic cationic exchange resin) polymer is employed as solid acid catalyst for the clean and less hazardous protection of carbonyl compounds as phenylhydrazones and 2,4-dintrophenylhydrazones in ethanol under reflux conditions. The reactions proceed very smoothly and the yields of the derivatives are excellent. Copyright Taylor & Francis, Inc.
- Niknam, Khodabakhsh,Kiasat, Ali Reza,Karimi, Sadegh
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p. 2231 - 2236
(2007/10/03)
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- In situ alcohol oxidation-protection reactions
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The one-pot conversion of primary and secondary alcohols into phenylhydrazones and 2,4-dintrophenylhydrazones is reported using chromium trioxide supported on silica gel and phenylhydrazines or 2,4- dintrophenylhydrazines under solvent-free conditions. This oxidation arylhydrazone formation reaction has been applied to a range of aliphatic and benzylic alcohols. Copyright Taylor & Francis, Inc.
- Kiasat,Kazemi,Nourbakhsh
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p. 1555 - 1558
(2007/10/03)
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- Solventless rapid synthesis of oxime, semicarbazone, and phenylhydrazone derivatives from carbonyl compounds under microwave conditions
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A rapid and efficient method for the synthesis of oximes, semicarbazones, and phenylhydrazones has been reported under solventless conditions using microwave irradiation. CSIRO 2005.
- Kamakshi,Reddy, Boreddy S. R.
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p. 603 - 606
(2007/10/03)
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- The regiospecific Fischer indole reaction in choline chloride· 2ZnCl2 with product isolation by direct sublimation from the ionic liquid
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The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride·2ZnCl2; exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.
- Morales, Raul Calderon,Tambyrajah, Vasuki,Jenkins, Paul R.,Davies, David L.,Abbott, Andrew P.
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p. 158 - 159
(2007/10/03)
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- Electrochemical formation of methoxy- and cyano(phenylazo)alkanes from aldehyde and ketone phenylhydrazones
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Several aldehyde and ketone phenylhydrazones were electrooxidized in MeOH. Electrooxidation in the presence of KI or tetraethylammonium p-toluenesulfonate as the supporting electrolyte afforded the corresponding methoxy(phenylazo)alkanes, whereas electrooxidation in the presence of KI, NaCN, and HOAc afforded the cyano(phenylazo)alkanes.
- Okimoto, Mitsuhiro,Takahashi, Yukio,Kakuchi, Toyoji
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p. 2057 - 2063
(2007/10/03)
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- Rearrangement of 3,3-Disubstituted 1-Aryl-4,5-dihydro-5-oxo-3H-1,2,4-triazolium Tetrafluoroborates; Part 2. A Convenient Synthesis of 1,5-Annulated 1,2-Dihydro-2-phenyl-3H-1,2,4-triazol-3-ones
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1-Isocyanato-1-(phenylazo)cycloalkanes 3 react with tetrafluoroboric acid to yield 3-spiro substituted 4,5-dihydro-5-oxo-1-phenyl-3H-1,2,4-triazolium tetrafluoroborates 4.Compounds 4 rearrange with ring expansion in good yield to give, after basic workup,
- Gstach, Hubert,Seil, Patrick
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p. 808 - 815
(2007/10/02)
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- MECHANISM OF THE FISCHER INDOLE SYNTHESIS. QUANTUM-CHEMICAL INTERPRETATION OF THE REARRANGEMENT OF SUBSTITUTED CYCLOHEXANONE ARYLHYDRAZONES TO TETRAHYDROCARBAZOLES
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Calculations of a number of model structures within the scheme of Fischer indole synthesis were made on the basis of a bonding variant of perturbation theory in the self-consistent-field (SCF) MO LCAO method.A quantum-chemical interpretation of the effect of substituents on the course of the thermal process is given.The kinetics of the thermal and acid-catalyzed indolization of substituted cyclohexanone arylhydrazones to tetrahydrocarbazoles were studied by spectrophotometry.It was shown that the experimental data are in satisfactory agreement with the calculated values. It was concluded that a concerted mechanism ( a -sigma-tropic shift) for the step involving the formation of a carbon-carbon bond in the Fischer reaction is preferred.
- Visotskii, Yu. B.,Przheval'skii, N. M.,Zemskii, B. P.,Grandberg, I. I.,Kostromina, L. Yu.
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p. 713 - 722
(2007/10/02)
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- Insecticide evaporator comprising a stabilizer
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Insecticide evaporator comprising at least one volatile phosphoric ester insecticide, an agent for stabilizing the said ester against decomposition by protonization and used in an amount of 0.2 to 20% based on the weight of phosphoric ester, characterized in that the stabilizing agent contains at least one compound selected from the compounds of the chemical class of 1,3-benzodioxoles and at least one diazene.
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- Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator
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An evaporator system adapted for emitting insect killing vapors of an insecticide therefrom and comprising a liquid or solid composition enclosed therein, said insecticide consisting in at least one volatile phosphoric acid ester which is stabilized by at least one diazene compound.
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