946-82-7

Usage

InChI:InChI=1/C12H16N2/c1-3-7-11(8-4-1)13-14-12-9-5-2-6-10-12/h1,3-4,7-8,13H,2,5-6,9-10H2

Upstream product

• 108-94-1 cyclohexanone 
• 100-63-0 phenylhydrazine 
• 2720-41-4 cyclohexanethione 
• 4410-13-3 1-(methylthio)cyclohexene 
• 1589-61-3 cyclohexanone semicarbazone 
• 108-88-3 toluene 
• 15786-82-0 thioacetic acid S-cyclohex-1-enyl ester 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 942-01-8 1,2,3,4-tetrahydrocarbazole 
• 13369-62-5 1-Phenylazo-cyclohexan-1-ol-acetat 
• 112382-67-9 4-(2-Phenyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-phenol 
• 80278-95-1 3-(4-Methoxy-phenyl)-2-phenyl-2,3a,4,5,6,7-hexahydro-benzo[1,2,3]diazaphosphole 3-sulfide 
• 1775-86-6 5,6,7,8,8a,9-hexahydro-4bH-carbazole 
• 74830-09-4 cyclohexanespiro-2'-(4'-phenyl-1',3',4'-thiadiazolidine-5-thione) 
• 73150-79-5 2-phenyl-1,2,4-triaza-spiro[4.5]decan-3-one 
• 5311-87-5 2-cyclohexylidene-1-methyl-1-phenylhydrazine 
• 112382-68-0 2-(2-Phenyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-phenol 
• 108-94-1 cyclohexanone 
• 98-95-3 nitrobenzene 
• 81323-21-9 N-Phenyl-N'-1-hydroxylaminocyclohexylhydrazine 
• 950-32-3 1-Hydroperoxid-1-phenylazo-cyclohexen 
• 104-94-9 4-methoxy-aniline 

Relevant academic research and scientific papers

HYDRAZONOPYRROLIDINE DERIVATIVES FOR USE IN PREVENTING AND/OR TREATING DISORDERS ASSOCIATED TO ACINETOBACTER BAUMANNII

The present invention relates to compounds of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated to Acinetobacter baumannii. The present invention al

Simple and efficient approach for synthesis of hydrazones from carbonyl compounds and hydrazides catalyzed by meglumine

A simple, environmentally benign protocol for synthesis of hydrazones from carbonyl compounds and hydrazides has been developed in the presence of meglumine in aqueous-ethanol media at room temperature. The salient features of the present protocol are mild reaction conditions, short reaction time, high yields, operational simplicity, metal-free, applicability toward large-scale synthesis, and biodegradable and inexpensive catalyst.

Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions

A highly selective and efficient method for the synthesis of 5-trifluoromethylated and 5-perfluoroalkylated pyrazoles has been developed which relies on the cyclization of hydrazine dianions with ethyl perfluorocarboxylates. The pyrazoles prepared were ev

Development of solvent-free ambient mass spectrometry for green chemistry applications

Green chemistry minimizes chemical process hazards in many ways, including eliminating traditional solvents or using alternative recyclable solvents such as ionic liquids. This concept is now adopted in this study for monitoring solvent-free reactions and analysis of ionic liquids, solids, and catalysts by mass spectrometry (MS), without using any solvent. In our approach, probe electrospray ionization (PESI), an ambient ionization method, was employed for this purpose. Neat viscous room-temperature ionic liquids (RTILs) in trace amounts (e.g., 25 nL) could be directly analyzed without sample carryover effect, thereby enabling high-throughput analysis. With the probe being heated, it can also ionize ionic solid compounds such as organometallic complexes as well as a variety of neat neutral solid chemicals (e.g., amines). More importantly, moisture-sensitive samples (e.g., [bmim][AlCl4]) can be successfully ionized. Furthermore, detection of organometallic catalysts (including air-sensitive [Rh-MeDuPHOS][OTf]) in ionic liquids, a traditionally challenging task due to strong ion suppression effect from ionic liquids, can be enabled using PESI. In addition, PESI can be an ideal approach for monitoring solvent-free reactions. Using PESI-MS, we successfully examined the alkylation of amines by alcohols, the conversion of pyrylium into pyridinium, and the condensation of aldehydes with indoles as well as air- and moisture-sensitive reactions such as the oxidation of ferrocene and the condensation of pyrazoles with borohydride. Interestingly, besides the expected reaction products, the reaction intermediates such as the monopyrazolylborate ion were also observed, providing insightful information for reaction mechanisms. We believe that the presented solvent-free PESI-MS method would impact the green chemistry field.

Oxidized single-walled carbon nanotubes (swcns-cooh) as a new catalyst for the protection of carbonyl groups as hydrazones

Nano-materials are considered as suitable heterogeneous catalysts for many organic reactions. Herein oxidized carbon nanotube (SWCNTs-COOH) has been reported as a heterogeneous catalyst, for protection of carbonyl groups as hydrazones in EtOH at 80 C. The reactions proceed smoothly with good to excellent yields, and the SWCNTs-COOH used can be recycled.

Efficient solvent-free synthesis of thiazolidin-4-ones from phenylhydrazine and 2,4-dinitrophenylhydrazine

An efficient solvent-free synthesis of thiazolidinones from reaction of mercaptoacetic acid, aldehydes (benzaldehyde and valeraldehyde) or ketones (cyclopentanone and cyclohexanone), and hydrazines (phenylhydrazine and 2,4-dinitrophenylhydrazine) is reported. The compounds were generally characterized by spectroscopic techniques and specifically for 2-cyclohexanyl-3-(N-phenyl)-1,3-thiazolidin-4-one by X-ray crystallography.

VIRAL POLYMERASE INHIBITORS

The present invention relates to viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV), processes for their preparation and their use in the treatment of infections.

A new approach to difficult Fischer synthesis: The use of zinc chloride catalyst in triethylene glycol under controlled microwave irradiation

Application of triethylene glycol with catalytic quantity of zinc chloride (ZnCl2/TEG) is described as a new and efficient reaction medium for a difficult Fischer synthesis, leading to sensitive indoles. Transformation of the 3-acetyl-1-methylthiocycloalka[c]pyridine phenylhydrazones and p-methoxyphenylhydrazones into the 2-(2-pyridyl)indoles and 5-methoxy-2-(2- pyridyl)indoles, which are the synthons in our total synthesis of the sempervirine-type alkaloids, is carried out under controlled microwave irradiation in dry zinc chloride solution (0.16 M) in TEG. This protocol produces indoles from acetophenone or cyclohexanone via their phenylhydrazones in excellent yields.

Solventless rapid synthesis of oxime, semicarbazone, and phenylhydrazone derivatives from carbonyl compounds under microwave conditions

A rapid and efficient method for the synthesis of oximes, semicarbazones, and phenylhydrazones has been reported under solventless conditions using microwave irradiation. CSIRO 2005.

Dowex polymer-mediated protection of carbonyl groups

Dowex (strongly acidic cationic exchange resin) polymer is employed as solid acid catalyst for the clean and less hazardous protection of carbonyl compounds as phenylhydrazones and 2,4-dintrophenylhydrazones in ethanol under reflux conditions. The reactions proceed very smoothly and the yields of the derivatives are excellent. Copyright Taylor & Francis, Inc.