Synthesis of 3-amino-5H-pyrrolo[2,3-e]-1,2,4-triazines by Sonogashira/copper(I)-catalyzed heteroannulation
A Sonogashira/copper(I)-catalyzed heteroannulation sequence was developed to convert 3,5-diamino-6-chloro-1,2,4-triazines to the corresponding 3-amino-5H-pyrrolo[2,3-e]-1,2,4-triazine derivatives in good yields.
The invention relates to (among other things) oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
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(2010/12/17)
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