946786-56-7

Basic information

• Product Name: 5-BROMO-2-[2-(4-MORPHOLINYL)ETHOXY]ANILINE
• Synonyms: 5-BROMO-2-[2-(4-MORPHOLINYL)ETHOXY]ANILINE
• CAS NO: 946786-56-7
• Molecular Formula: C₁₂H₁₇BrN₂O₂
• Molecular Weight: 301.17958
• Mol File: 946786-56-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-BROMO-2-[2-(4-MORPHOLINYL)ETHOXY]ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-[2-(4-MORPHOLINYL)ETHOXY]ANILINE(946786-56-7)
• EPA Substance Registry System: 5-BROMO-2-[2-(4-MORPHOLINYL)ETHOXY]ANILINE(946786-56-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 946786-56-7(Hazardous Substances Data)

Upstream product

• 1101858-59-6 4-[2-(4-bromo-2-nitrophenoxy)ethyl]morpholine 

Downstream Products

• 1101858-60-9 N-[5-bromo-2-(2-morpholinoethoxy)phenyl]-2-(1-naphthalenyl)acetamide 
• 1101858-62-1 N-[5-bromo-2-(2-morpholinoethoxy)phenyl]benzenesulfonamide 
• 1101858-61-0 N-[5-bromo-2-(2-morpholinoethoxy)phenyl]-3-phenylpropanamide 
• 1101858-63-2 4-bromo-N-[5-bromo-2-(2-morpholinoethoxy)phenyl]benzenesulfonamide 
• 1243052-35-8 1-(5-bromo-2-(2-morpholinoethoxy)phenyl)-3-(2-chlorophenyl)urea 
• 1243052-28-9 1-(5-bromo-2-(2-morpholinoethoxy)phenyl)-3-phenylurea 
• 1243052-33-6 1-(5-bromo-2-(2-morpholinoethoxy)phenyl)-3-(4-methoxyphenyl)urea 
• 1615223-19-2 5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(2-morpholinoethoxy)aniline 

Relevant articles and documents

Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease

Dual-target-directed 1,3-diphenylurea derivatives were designed by hybridizing BACE 1 inhibitor 1 with metal chelator LR-90. A database consisted of 1,3-diphenylurea derivatives was built and screened by the pharmacophore model (Hypo 1) of BACE 1 inhibitor. Based on the predicted results, 11 compounds (6a-d, 9a-g) with favorable Fitvalues were selected, synthesized and evaluated for their BACE 1 inhibitory activities, which showed that the predicted results were in good agreement with the experimental values. Besides, the synthesized compounds also displayed the ability to chelate metal ions. The most effective BACE 1 inhibitor 9f (27.85 ± 2.46 μmol/L) was selected for further receptor-binding studies, the result of which indicated that an essential hydrogen bonds was formed between the urea group of 9f and the catalytic aspartate Asp228.

Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors

The pharmacophore model of arylpiperazine amide derivatives was built using Discovery Studio 2.0 software package and the best pharmacophore model (Hypo 1) was validated by Enrichment and ROC method (EF at 2%, 5% and 10% are 30.6, 12.2 and 7.7; AUC of the