Recoverable resin-supported pyridylamide ligand for microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylations: Enantioselective synthesis of baclofen
(Matrix presented) The syntheses of a series of 4-monosubstituted pyridylamides and a resin-supported pyridylamide are described. The ligands were evaluated in the microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylation. The reaction affo
Belda, Oscar,Lundgren, Stina,Moberg, Christina
p. 2275 - 2278
(2007/10/03)
Enantioselective syntheses of (R)-3-phenyl GABA, (R)-baclofen and 4-arylpyrrolidin-2-ones
Enantioselective synthesis of (R)-4-amino-3-phenylbutyric acid and (R)-baclofen has been achieved through a diastereoselective conjugate addition of cyanide to enantiomerically pure 2-(2-arylethenyl)oxazolines, followed by chemoselective reduction into cyclic amidines.
Langlois, Nicole,Dahuron, Nathalie,Wang, Hai-Shan
p. 15117 - 15126
(2007/10/03)
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