948027-43-8

Basic information

• Product Name: 3-pyr-Cytisine
• Synonyms: 3-pyr-Cytisine
• CAS NO: 948027-43-8
• Molecular Formula: C16H17N3O
• Molecular Weight: 267.32568
• Mol File: 948027-43-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-pyr-Cytisine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-pyr-Cytisine(948027-43-8)
• EPA Substance Registry System: 3-pyr-Cytisine(948027-43-8)

Safety Data

• Hazardous Substances Data: 948027-43-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridin-3''-yl-cytisine is used as an antidepressant agent for its ability to alleviate symptoms of depression and improve mood. It modulates the activity of nicotinic acetylcholine receptors, which play a crucial role in regulating mood, cognition, and emotional processing. This selective targeting allows for a more focused therapeutic effect with potentially fewer side effects compared to traditional antidepressants.
Used in Neurological Research:
3-Pyridin-3''-yl-cytisine is used as a research tool for studying the role of nicotinic acetylcholine receptors in various neurological and psychiatric disorders. Its ability to selectively modulate these receptors makes it a valuable compound for investigating the underlying mechanisms of diseases such as Alzheimer's, Parkinson's, and schizophrenia, as well as for developing novel therapeutic strategies.
Used in Nicotine Addiction Treatment:
3-Pyridin-3''-yl-cytisine is used as a potential treatment for nicotine addiction due to its ability to alter catecholamine homeostasis and response to nicotine in PC12 cells. This suggests that it may help reduce the rewarding effects of nicotine and decrease the cravings associated with smoking cessation, making it a promising candidate for the development of smoking cessation aids and therapies.

Upstream product

• 1558021-83-2 C₂₁H₂₅N₃O₃ 
• 207390-62-3 8-oxo-1,5,6,8-tetrahydro-2H,4H-1,5-methano-pyrido[1,2-a][1,5]diazocine-3-carboxylic acid tert-butyl ester [N-tboccytisine] 
• 207390-11-2 9-bromo-8-oxo-1,5,6,8-tetrahydro-2H,4H-1,5-methano-pyrido[1,2-a][1,5]diazocine-3-carboxylic acid tert-butyl ester [3-bromo-N-tboc-cytisine] 
• 485-35-8 cytisine 

Relevant articles and documents

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs

3,7-Diazabicyclo[3.3.1]nonane (bispidine) based nicotinic acetylcholine receptor (nAChR) ligands have been synthesized and evaluated for nAChRs interaction. Diverse spacer motifs were incorporated between the hydrogen bond acceptor (HBA) part and a variety of substituted (hetero)aryl moieties. Bispidine carboxamides bearing spacer motifs often showed high affinity in the low nanomolar range and selectivity for the α4β2* nAChR. Compounds 15, 25, and 47 with Ki values of about 1 nM displayed the highest affinities for α4β2* nAChR. All evaluated compounds are partial agonists or antagonists at α4β2*, with reduced or no effects on α3β4* with the exception of compound 15 (agonist), and reduced or no effect at α7 and muscle subtypes.

CYTISINE AND ACETYLCHOLINE ANALOGS AND METHODS OF TREATING MOOD DISORDERS

The present invention relates to compounds which are derivatives of cytisine or acetylcholine which exhibit activity as agonists, partial agonists or antagonists of nicotinic acetylcholine receptors and may be used in modulating these receptors and in tre