cas 949096-34-8, (4R)-4-AMINO-4-PHENYLBUTAN-1-OL

Articles about 949096-34-8Total 7 be found

N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols
N-Hydroxyphthalimide-catalyzed chemoselective benzylic C(sp3)-H amination of unprotected arylalkanols using bis(2,2,2-trichloroethyl)azodicarboxylate has been developed. The use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent plays a critical role in chemoselectivity. The conversion of an aminated product to the corresponding free amino alcohol was also demonstrated.
Shibuya, Masatoshi,Orihashi, Takayuki,Li, Yamei,Yamamoto, Yoshihiko
supporting information
p. 8742 - 8745
(2021/09/07)

Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions
Cinchona alkaloid-derived chiral catalysts represent one of the most widely applied classes of organocatalysts, which have been successfully utilized in the promotion of a wide variety of asymmetric reactions. Cinchona alkaloids exist in nature as pseudoe
Hu, Bin,Bezpalko, Mark W.,Fei, Chao,Dickie, Diane A.,Foxman, Bruce M.,Deng, Li
supporting information
p. 13913 - 13920
(2018/10/20)

Synthesis of 1,4-amino alcohols by Grignard reagent addition to THF and N-tosyliminobenzyliodinane
The synthesis of 1,4-amino alcohols from THF treated with N-tosyliminobenzyliodinane (PhINTs) followed by a Grignard reagent under mild reaction conditions at room temperature is described herein. Various Grignard reagents were shown to be compatible, furnishing the corresponding 4-substituted-N-1,4-tosylamino alcohols in good to excellent yields. A partial or full detosylation of the N-tosyl-1,4-amino alcohol was observed in instances involving a sterically bulky Grignard reagent, leading to the deprotected 1,4-amino alcohol product in moderate to good yields. The synthetic utility of this protocol was demonstrated by the synthesis of a 5-substituted-N-tosyl-1,5-amino alcohol from THP and the conversion of two examples to their corresponding γ-lactam and pyrrolidine adducts.
Tejo, Ciputra,See, Yang Feng Anders,Mathiew, Mitch,Chan, Philip Wai Hong
supporting information
p. 844 - 848
(2016/01/15)

BRANCHED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.
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Paragraph 0293

(2014/02/15)

Synthesis of 2-substituted pyrrolidines from nitriles
A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purificati
Ramachandran, P. Veeraraghavan,Mitsuhashi, Wataru,Nicponski, Daniel R.
supporting information
p. 5001 - 5003
(2013/08/28)

Convenient synthesis of stable aldimine - Borane complexes, chiral δ-amino alcohols, and γ-substituted GABA analogues from nitriles
A one-pot synthesis of stable aldimine-trialkylborane adducts, the first synthesis of C- and N-deuterated imine-borane complexes, and their application for a highly enantioselective (84-99% ee) synthesis of δ-amino alcohols and γ-substituted γ-aminobutyri
Ramachandran, P. Veeraraghavan,Biswas, Debanjan
p. 3025 - 3027
(2008/02/10)