949096-34-8

Usage

Uses

Used in Organic Synthesis:
(4R)-4-AMINO-4-PHENYLBUTAN-1-OL is used as a chiral building block in organic synthesis for the creation of enantioselective compounds. Its unique structure allows for the development of new molecules with specific stereochemistry, which is crucial in producing biologically active molecules with desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4R)-4-AMINO-4-PHENYLBUTAN-1-OL is utilized as a component in drug development. Its chiral nature and functional groups make it a promising candidate for the synthesis of new drugs with improved efficacy and selectivity. (4R)-4-AMINO-4-PHENYLBUTAN-1-OL can be incorporated into various drug molecules to enhance their pharmacological properties and target specific biological pathways.
Used in Chemical Research:
(4R)-4-AMINO-4-PHENYLBUTAN-1-OL is also used in chemical research to explore its properties and potential applications. Researchers can study its reactivity, stability, and interactions with other molecules to gain insights into its behavior and develop new methodologies for its synthesis and use.
Overall, (4R)-4-AMINO-4-PHENYLBUTAN-1-OL is a versatile compound with significant potential in various industries, particularly in organic synthesis and pharmaceutical development, due to its unique structure and properties.

InChI:InChI=1/C10H15NO/c11-10(7-4-8-12)9-5-2-1-3-6-9/h1-3,5-6,10,12H,4,7-8,11H2/t10-/m1/s1

Upstream product

• 39755-03-8 4-hydroxy-1-phenyl-butan-1-one 
• 85116-38-7 (+)-diisopinocampheylallylborane 
• 1398626-52-2 (S)-4-amino-4-phenylbutyric acid sodium salt 
• 1398626-55-5 ((S)-3-cyano-1-phenylpropyl)carbamic acid tert-butyl ester 
• 100-47-0 benzonitrile 
• 1730-25-2 allylmagnesium bromide 
• 107045-41-0 3-Benzoylpropionic Acid,O-Methyloxime 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 936499-93-3 (S)-3-amino-3-phenyl-1-propanol hydrochloride 
• 1150560-58-9 methanesulfonic acid (S)-3-tert-butoxycarbonylamino-3-phenylpropyl ester 
• 82769-76-4 (S)-3-amino-3-phenylpropanol 
• 718611-17-7 S-(3-hydroxy-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 
• 109-99-9 tetrahydrofuran 

Downstream Products

• 558442-49-2 4-[(t-butoxycarbonyl)-amino]-4-phenylbutanol 
• 865188-31-4 tert-butyl (1S)-4-hydroxy-1-phenylbutylcarbamate 
• 42331-01-1 4-chloro-1-phenyl-butylamine 

Relevant academic research and scientific papers

N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols

N-Hydroxyphthalimide-catalyzed chemoselective benzylic C(sp3)-H amination of unprotected arylalkanols using bis(2,2,2-trichloroethyl)azodicarboxylate has been developed. The use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent plays a critical role in chemoselectivity. The conversion of an aminated product to the corresponding free amino alcohol was also demonstrated.

Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions

Cinchona alkaloid-derived chiral catalysts represent one of the most widely applied classes of organocatalysts, which have been successfully utilized in the promotion of a wide variety of asymmetric reactions. Cinchona alkaloids exist in nature as pseudoe

Synthesis of 1,4-amino alcohols by Grignard reagent addition to THF and N-tosyliminobenzyliodinane

The synthesis of 1,4-amino alcohols from THF treated with N-tosyliminobenzyliodinane (PhINTs) followed by a Grignard reagent under mild reaction conditions at room temperature is described herein. Various Grignard reagents were shown to be compatible, furnishing the corresponding 4-substituted-N-1,4-tosylamino alcohols in good to excellent yields. A partial or full detosylation of the N-tosyl-1,4-amino alcohol was observed in instances involving a sterically bulky Grignard reagent, leading to the deprotected 1,4-amino alcohol product in moderate to good yields. The synthetic utility of this protocol was demonstrated by the synthesis of a 5-substituted-N-tosyl-1,5-amino alcohol from THP and the conversion of two examples to their corresponding γ-lactam and pyrrolidine adducts.

BRANCHED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

Synthesis of 2-substituted pyrrolidines from nitriles

A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purificati

Convenient synthesis of stable aldimine - Borane complexes, chiral δ-amino alcohols, and γ-substituted GABA analogues from nitriles

A one-pot synthesis of stable aldimine-trialkylborane adducts, the first synthesis of C- and N-deuterated imine-borane complexes, and their application for a highly enantioselective (84-99% ee) synthesis of δ-amino alcohols and γ-substituted γ-aminobutyri

Phosphinylalkanoyl imino acids

Phosphinylalkanoyl imino acids useful in the treatment of hypertension are disclosed.