95037-35-7Relevant articles and documents
ANTIVIRAL COMPOUNDS
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Paragraph 0730, (2015/03/13)
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models
Patel, Snahel,Cohen, Frederick,Dean, Brian J.,De La Torre, Kelly,Deshmukh, Gauri,Estrada, Anthony A.,Ghosh, Arundhati Sengupta,Gibbons, Paul,Gustafson, Amy,Huestis, Malcolm P.,Le Pichon, Claire E.,Lin, Han,Liu, Wendy,Liu, Xingrong,Liu, Yichin,Ly, Cuong Q.,Lyssikatos, Joseph P.,Ma, Changyou,Scearce-Levie, Kimberly,Shin, Young G.,Solanoy, Hilda,Stark, Kimberly L.,Wang, Jian,Wang, Bei,Zhao, Xianrui,Lewcock, Joseph W.,Siu, Michael
, p. 401 - 418 (2015/01/30)
Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions to infer a binding mode and specific design parameters to optimize for CNS druglike molecules, we came to focus on the di(pyridin-2-yl)amines because of their combination of desirable potency and good brain penetration following oral dosing. Our lead inhibitor GNE-3511 (26) displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that specific pharmacological inhibition of DLK may have therapeutic potential in multiple indications.
Substituted pyridyl compounds, herbicidal compositions and method of use
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, (2008/06/13)
Substituted pyridyl compounds, e.g. 2,6-dichloro-4(2-(2,2,2-trichloroethyl)oxiranyl) pyridine; herbicidal compositions containing such compounds and method for the control of undesired vegetation using these compositions.