951889-31-9Relevant articles and documents
Synthesis and characterization of naphth-annelated thiophene analogs
Clement, J. Arul,Mohanakrishnan, Arasambattu K.
experimental part, p. 2340 - 2350 (2010/06/12)
Synthesis of symmetrical and unsymmetrical naphth-annelated thienyl heterocycles has been achieved via thionation of hydroxyketones/diketones using Lawesson's reagent. Photophysical studies of 1,3-disubstituted naphtho[c]thiophene analogs are presented. Electro-oxidative behavior of these naphtha-annelated thiophenes are investigated using cyclic voltammeter.
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system
Harrak,Rosell,Daidone,Plescia,Schillaci,Pujol
, p. 4876 - 4890 (2008/03/12)
A series of substituted derivatives containing the 1,4-benzodioxine or pyrrole nucleus are described. All the newly synthesized compounds were examined for their in vitro and in vivo anti-inflammatory activity. Several derivatives, including (S)-2, 14 and 17, showed more anti-inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 were equipotent to ibuprofen. Compound 17 was the most outstanding derivative because of its remarkable in vivo anti-inflammatory activity. In this paper, we examine and discuss the structure-activity relationships and anti-inflammatory activities of these compounds.
