95308-00-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(Oxazolo[4,5-b]pyridin-2-yl)aniline is utilized as a building block in the synthesis of various biologically active molecules. Its role in the creation of new pharmaceutical compounds is significant, as it can contribute to the development of drugs with diverse therapeutic applications.
Used in Medicinal Chemistry Research:
2-(Oxazolo[4,5-b]pyridin-2-yl)aniline is employed as a valuable and versatile compound in the field of medicinal chemistry. Its unique structure allows for the exploration of its potential in the treatment of various diseases, including its studied properties for anti-cancer, anti-inflammatory, and antibacterial effects.
Used in Cancer Treatment Research:
2-(Oxazolo[4,5-b]pyridin-2-yl)aniline is investigated for its potential as an anti-cancer agent. Its role in cancer treatment research is to explore how it can be used to inhibit the growth and progression of cancer cells, potentially leading to the development of new cancer therapies.
Used in Inflammation and Infection Management:
2-(Oxazolo[4,5-b]pyridin-2-yl)aniline is also being studied for its anti-inflammatory and antibacterial properties. This research aims to understand how the compound can be used in the management of inflammation and the treatment of bacterial infections, offering new possibilities for therapeutic interventions in these areas.

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 118-48-9 isatoic anhydride 
• 118-92-3 anthranilic acid 

Downstream Products

• 925432-07-1 C₂₁H₁₇N₃O₄ 
• 925432-08-2 C₂₁H₁₈N₄O₂ 

Relevant academic research and scientific papers

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an IC50 of 2.6 μM as a chemical starting point for the development of potent FAAH inhibitors. Preliminary hit-to-lead optimisation resulted in 2-(4-phenylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4i, with an IC50 of 0.35 μM.

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

SIRT1 is an NAD+-dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. Activation of SIRT1 by resveratrol (1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. Herein, we describe the identification and SAR of a series of oxazolo[4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol.

Oxazoline chemistry part III. Synthesis and characterisation of [2-(2′-anilinyl)-2-oxazolines] and some related compounds

The syntheses and characterisation of a series of chiral and achiral 2-(aminophenyl)-2-oxazolines and some related compounds is reported. All of the derivatives have been produced by a one-step procedure involving the treatment of isatoic anhydride (i.e.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.