955403-59-5

Basic information

• Product Name: Benzenepropanal, 2,4,5-trifluoro-
• Synonyms: Benzenepropanal, 2,4,5-trifluoro-;3-(2,4,5-trifluorophenyl)propanal
• CAS NO: 955403-59-5
• Molecular Formula: C₉H₇F₃O
• Molecular Weight: 188.1464896
• Mol File: 955403-59-5.mol

Chemical Properties

• Boiling Point: 202.6°C at 760 mmHg
• Flash Point: 80.9°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.291mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: Benzenepropanal, 2,4,5-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanal, 2,4,5-trifluoro-(955403-59-5)
• EPA Substance Registry System: Benzenepropanal, 2,4,5-trifluoro-(955403-59-5)

Safety Data

• Hazardous Substances Data: 955403-59-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7F3O/c10-7-5-9(12)8(11)4-6(7)2-1-3-13/h3-5H,1-2H2

Upstream product

• 17533-08-3 1-iodo-2,4,5-trifluorobenzene 
• 107-18-6 allyl alcohol 
• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 888321-36-6 ethyl 3-(2,4,5-trifluorophenyl)acrylate 

Downstream Products

• 955403-71-1 C₁₇H₂₀F₃N₃ 
• 1365321-47-6 (R)-3-(2,4,5-trifluorophenyl)propane-1,2-diol 
• 1365321-55-6 (2S)-3-(2,4,5-trifluorophenyl)propane-1,2-diol 
• 1365321-51-2 (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile 
• 1283096-74-1 (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile 
• 957025-32-0 (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid 
• 1365321-53-4 (R)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 
• 1352613-29-6 (S)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 

Relevant articles and documents

Pd-catalyzed reductive cleavage of N-N bond in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates with PMHS: Application to a formal enantioselective synthesis of (R)-sitagliptin

An environmentally benign approach involving Pd-catalyzed reductive N-N bond cleavage in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates leading to the synthesis of N-(tert-butoxy)carbamates under very mild conditions has been described. PMHS serves as an inexpensive source of hydride in MeOH/deionized H2O medium. This protocol has been successfully applied in the formal synthesis of (R)-sitagliptin, an anti-diabetic drug.

Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5- trifluorophenyl)butanoic acid: A synthon for sitagliptin and its derivatives

A new synthetic strategy for (R)- and (S)-3-hydroxy-4-(2,4,5- trifluorophenyl)butanoic acid, a building block in the preparation of sitagliptin and its derivatives, was developed. Pd(OAc)2 catalyzed coupling of 2,4,5-trifluoro-1-iodobenzene wit

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PYRAZOLO-TETRAHYDRO PYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

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