- [123I]-celecoxib analogues as SPECT tracers of cyclooxygenase-2 in inflammation
-
We report the synthesis and evaluation of a series of iodinated celecoxib analogues as cyclooxygenase-2 (COX-2)-targeted single photon emission computerized tomography (SPECT) imaging agents for the detection of inflammation. The structure-activity relati
- Uddin, Md. Jashim,Crews, Brenda C.,Ghebreselasie, Kebreab,Tantawy, Mohammed N.,Marnett, Lawrence J.
-
-
Read Online
- Substituted piperazines as metabotropic glutamate receptor antagonists
-
The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.
- -
-
Page/Page column 17
(2008/06/13)
-
- MGluR5 modulators VI
-
The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
- -
-
Page/Page column 10-11
(2008/06/13)
-
- MGluR5 modulators V
-
The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
- -
-
Page/Page column 16
(2008/06/13)
-