957230-68-1

Basic information

• Product Name: 3,6-dibroMopyrazine-2-carboxylic acid
• Synonyms: 3,6-dibromo-2-Pyrazinecarboxylic acid;2-Pyrazinamine, 5-bromo-3-(bromomethyl)-,hydrobromide (1:1);3,6-dibroMopyrazine-2-carboxylic acid
• CAS NO: 957230-68-1
• Molecular Formula: C5H2Br2N2O2
• Molecular Weight: 281.88958
• Mol File: 957230-68-1.mol

Chemical Properties

• Boiling Point: 368.724°C at 760 mmHg
• Flash Point: 176.798°C
• Appearance: /
• Density: 2.334g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,6-dibroMopyrazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-dibroMopyrazine-2-carboxylic acid(957230-68-1)
• EPA Substance Registry System: 3,6-dibroMopyrazine-2-carboxylic acid(957230-68-1)

Safety Data

• Hazardous Substances Data: 957230-68-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3,6-Dibromopyrazine-2-carboxylic acid is utilized as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with diverse therapeutic applications. Its unique structure allows for the creation of a variety of functionalized compounds, enhancing the range of pharmaceutical agents available for treating various diseases and conditions.
Used in Agrochemical Production:
In the agrochemical industry, 3,6-Dibromopyrazine-2-carboxylic acid serves as a key intermediate for the synthesis of various agrochemicals. Its incorporation into these products can lead to the development of more effective pesticides, herbicides, and other agricultural chemicals, thereby improving crop protection and yield.
Used in Organic Synthesis:
3,6-Dibromopyrazine-2-carboxylic acid is employed as a building block in organic synthesis, enabling the preparation of a wide array of functionalized compounds. Its presence in these syntheses facilitates the creation of novel molecules with potential applications in various industries, such as materials science, chemical engineering, and specialty chemicals.
Used in Antimicrobial Applications:
3,6-Dibromopyrazine-2-carboxylic acid has been studied for its antimicrobial properties, making it a potential candidate for use in the development of new antimicrobial agents. Its ability to combat various microorganisms could contribute to the fight against antibiotic-resistant bacteria and other infectious diseases.
Used in Anticancer Research:
3,6-Dibromopyrazine-2-carboxylic acid has also been investigated for its potential anticancer activities. As a result, 3,6-Dibromopyrazine-2-carboxylic acid may be used in the development of new anticancer drugs, offering a novel therapeutic approach to cancer treatment and potentially improving patient outcomes.

InChI:InChI=1/C5H2Br2N2O2/c6-2-1-8-4(7)3(9-2)5(10)11/h1H,(H,10,11)

Upstream product

• 5424-01-1 3-aminopyrazinoic acid 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 6966-01-4 methyl 3-amino-6-bromopyrazine-2-carboxylate 
• 13301-04-7 3,6-dibromopyrazine-2-carboxylic acid methyl ester 

Downstream Products

• 957230-70-5 3,6-dibromopyrazin-2-amine 

Relevant articles and documents

Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis

MAPKAPK5 has been proposed to play a role in regulation of matrix metalloprotease expression and so to be a potential target for intervention in rheumatoid arthritis. We present here the identification of a series of compounds against this target which are effective in both biochemical and cell assays. The expansion of the series is described, along with early SAR and pharmacokinetics for some representative compounds.

INHIBITORS OF JAK

The present invention relates to the use of novel compounds of Formula I, wherein the variables m, n, p, q, Q, r, R, R′, X, X′, Y, Z1, Z2, and Z3 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.

FUSED PYRAZINE COMPOUNDS AS THEIR SALTS, USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel salts of a [1.2.4]triazolo[1,5-a]pyrazine compound according to Formula I: The salts may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, and others.

FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.