5424-01-1

Basic information

• Product Name: 3-Aminopyrazine-2-carboxylic acid
• Synonyms: TIMTEC-BB SBB004179;3-AMINOPYRAZINE-2-CARBOXYLIC ACID;3-AMINO-2-PYRAZINECARBOXYLIC ACID;3-AMINOPIPERAZINE-2-CARBOXYLIC ACID;3-Aminophrazine-2-carboxylic acid;3-AMINOPYRAZINE-2-CARBOXYLIC ACIDCRYSTAL LINE;3-AMINOPYRAZINE-2-CARBOXYLIC ACID, 99+%;Pyrazinecarboxylic acid, 3-amino- (7CI,8CI,9CI)
• CAS NO: 5424-01-1
• Molecular Formula: C₅H₅N₃O₂
• Molecular Weight: 139.11
• EINECS: 226-558-7
• Product Categories: AMINOACID;Pyrazines;pharmacetical;Heterocyclic Compounds;Pyrazinecarboxylic Acid & Derivatives;Bases & Related Reagents;Heterocycles;Nucleotides;Building Blocks;Heterocyclic Building Blocks;amine | carboxylic acid
• Mol File: 5424-01-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 205-210 °C (dec.)(lit.)
• Boiling Point: 255.04°C (rough estimate)
• Flash Point: 196.5 °C
• Appearance: Yellow-greenish/Crystalline Powder
• Density: 1.4551 (rough estimate)
• Vapor Pressure: 3.68E-07mmHg at 25°C
• Refractive Index: 1.5900 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Sparingly) , Methanol (Slightly)
• PKA: 3.65±0.10(Predicted)
• BRN: 124835
• CAS DataBase Reference: 3-Aminopyrazine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminopyrazine-2-carboxylic acid(5424-01-1)
• EPA Substance Registry System: 3-Aminopyrazine-2-carboxylic acid(5424-01-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 5424-01-1(Hazardous Substances Data)

Usage

Chemical Properties

Pale Brown Crystalline Solid

Uses

Antidiabetic

InChI:InChI=1/C5H5N3O2/c6-4-3(5(9)10)7-1-2-8-4/h1-2H,(H2,6,8)(H,9,10)/p-1

Upstream product

• 6973-01-9 4-aminopteridine 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 487-21-8 Lumazine 
• 74688-61-2 ammonium 3-carbamoylpyrazine-2-carboxylate 
• 6164-78-9 pyrazine-2,3-dicarboxamide 
• 700-47-0 pteridin-4-one 
• 32587-10-3 3-aminopyrazine-2-carboxamide 

Downstream Products

• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 5049-61-6 2-Aminopyrazine 
• 20737-42-2 3-oxo-3,4-dihydropyrazine-2-carboxylic acid 
• 209627-20-3 N-benzyl-N-ethoxycarbonylmethyl-3-aminopyrazine-2-carboxamide 
• 209627-21-4 N-methoxycarbonylmethyl-N-(4-methoxyphenylmethyl)-3-aminopyrazine-2-carboxamide 
• 209627-22-5 N-(2,4-dimethoxyphenylmethyl)-N-methoxycarbonylmethyl-3-aminopyrazine-2-carboxamide 
• 209627-19-0 (R)-3-(3-Amino-pyrazine-2-carbonyl)-2-phenyl-thiazolidine-4-carboxylic acid ethyl ester 
• 209627-23-6 N-((1S)-1-methoxycarbonyl)ethyl-N-(4-methoxyphenylmethyl)-3-aminopyrazine-2-carboxamide 
• 209627-37-2 (3-Amino-pyrazin-2-yl)-[(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone 
• 155513-85-2 2-Phenylpyrazino<2,3-d><3,1>oxazin-4-one 
• 1030178-97-2 3-amino-N-[2-(4-chlorophenyl)ethyl]pyrazine-2-carboxamide 
• 36204-80-5 anilide of 3-aminopyrazinecarboxylic acid 
• 1204400-32-7 methyl 4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydiropyrazine-2-carboxylate 
• 1204400-34-9 4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydropyrazine-2-carboxyIic acid 

Relevant articles and documents

ALPHA 7 NICOTINIC ACETYLCHOLINE ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF

The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of al nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on al nAChRs in a mammal by administering an effective amount of a compound of Formula I.

A novel improved synthesis of 3-aminopyrazine-2-carboxylic acid

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