Cyclic imides are inhibitors of tumor necrosis factor α and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-(2,6-dioxo-3-piperidinyl)-4-azaisoindoline-1,3-dione.
-
(2008/06/13)
Cyclic amides
Cyclic amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 3-phenyl-3-(1-oxoisoindolin-2-yl)propionamide.
-
(2008/06/13)
Reactions of boroxazolidones with aromatic aldehydes. An easy route to derivatives of isoquinoline and iso-indolinone
Boroxazolidones 1 derived from glycine and phenylalanine react with aromatic aldehydes to form the corresponding imines. The product 3 from 1a with o-carboxybenzaldehyde is converted into 4-hydroxyisoquinoline-3-carboxylic acid 6 by dimethyl sulfate, foll
Nefkens,Zwanenburg
p. 6063 - 6066
(2007/10/02)
A Simple One-step Synthesis of N-Substituted Isoindolin-1-ones. Diastereofacially Selective Protonation of an Intermediate Isoindolinol
α-Amino acids and their methyl esters, arylamines, heterocyclic amines and, less efficiently, aryl substituted aliphatic amines, react with o-phthaldialdehyde in the presence of acetic acid to give N-substituted isoindolin-1-ones in excellent yield; deute
Grigg, Ronald,Gunaratne, H. Q. Nimal,Sridharan, Visuvanathar
p. 1183 - 1184
(2007/10/02)
Synthesis of the 5H-Pyrroloisoindole Ring with 1,3-Dipolar Cycloaddition Reactions
The 1,3-dipolar cycloaddition reaction between mesoionic oxazolines, formed from either 1,3-dihydro-2-substituted-2H-isoindole-1-carboxylic acids or 1,3-dihydro-1-oxo-α-substituted-2H-isoindole-2-acetic acids, and dimethylacetylene dicarboxylate has led t
New, J. S.,Yevich, J. P.
p. 1355 - 1360
(2007/10/02)
More Articles about upstream products of 96017-10-6