Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
Based on the structures of several lipophilic trioxolane antimalarial prototypes, we set out to determine which functional groups were associated with good antimalarial profiles and identify more polar (lower Log P/Log D) lead compounds with good physicoc
Dong, Yuxiang,Tang, Yuanqing,Chollet, Jacques,Matile, Hugues,Wittlin, Sergio,Charman, Susan A.,Charman, William N.,Tomas, Josefina Santo,Scheurer, Christian,Snyder, Christopher,Scorneaux, Bernard,Bajpai, Saroj,Alexander, Scott A.,Wang, Xiaofang,Padmanilayam, Maniyan,Cheruku, Srinivasa R.,Brun, Reto,Vennerstrom, Jonathan L.
p. 6368 - 6382
(2007/10/03)
Optimized liquid-phase oxidation
Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly effic
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Page/Page column 39-41
(2008/06/13)
Optimized liquid-phase oxidation
Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly effic
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Page/Page column 39-41
(2008/06/13)
PRODUCTION OF AROMATIC CARBOXYLIC ACIDS
A process for the production of an aromatic carboxylic acid comprising contacting in the presence of a catalyst, within a continuous flow reactor, one or more precursors of the aromatic carboxylic acid with an oxidant, such contact being effected with sai
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Page 28
(2008/06/13)
Synthesis and solubility properties of C60 fullerene derivatives bearing carboxy groups
Bis(4-tert-butoxycarbonylphenyl)diazomethanes have been prepared and treated with fullerene (C60) to give the corresponding 1,2-methano derivatives which upon hydrolysis with CF3CO2H gave the title compounds. The solubility of the latter in aqueous THF has been measured.
Tomioka, Hideo,Yamamoto, Katsutoshi
p. 63 - 66
(2007/10/03)
Photochemistry of Meta-Substituted and Para-Substituted Aromatic Polycarbonyl Compounds
Spectroscopic (λmax and ET) and photochemical (quantum yield of benzocyclobutenol formation ΦCB and Stern-Volmer quenching constant with diene KSV) properties for meta-substituted polyketones 1b-f, 2, and 5b, pa
Purification of 4,4'-benzophenonedicarboxylic acid
A process is described for purifying 4,4'-benzophenonedicarboxylic acid, useful in preparing thermoplastic polyesters yielding molded articles having high impact strength, wherein the acid contains aromatic monocarboxylic acid genetic impurity, which comp