SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS
The present invention provides novel substituted pyrimidinyl-amines that are useful as inhibitors of protein kinases, especially c-Jun N-terminal kinases (JNK) and pharmaceutical compositions thereof and methods of using the same for treating conditions responsive to the inhibition of the JNK pathway.
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Page/Page column 71; 72
(2009/04/25)
MALONONITRILE COMPOUND AND USE THEREOF
A nitrile compound shown by the formula (1) has an excel lent pesticidal activity and it is useful as an active ingredient of pesticide.
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Page/Page column 59
(2008/06/13)
Remarkably Distinctive Recognition of α-Alanine and α-Phenylalanine during the Water-Catalyzed Hydrolysis of an Activated Amide
The rate of the water-catalyzed hydrolysis of three activated amides in aqueous solution is significantly retarded by small amounts of α-phenylalanine as compared with the rate acceleration induced by other common α-amino acids not containing a benzyl group in their side chain.These contrasting effects emphasize the large hydrophobicity of α-phenylalanine and are of relevance for a better quantitative understanding of protein folding and molecular recognition processes involving proteins.
Streefland, Lisette,Blandamer, Michael J.,Engberts, Jan B. F. N.
p. 5769 - 5771
(2007/10/02)
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