96507-72-1

Basic information

• Product Name: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate
• Synonyms: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate;4-Chloro-3-formyl-5,6-dihydro-1(2H)-pyridinecarboxylic acid ethyl ester;4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester;ethyl 4-chloro-3-methanoyl-5,6-dihydro-2H-pyridine-1-carboxylate;ethyl 4-chloro-5-formyl-3,6-dihydropyridine-1(2H)-carboxylate;4-Chloro-5-formyl-3,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester
• CAS NO: 96507-72-1
• Molecular Formula: C₉H₁₂ClNO₃
• Molecular Weight: 217.64948
• EINECS: 306-150-6
• Mol File: 96507-72-1.mol

Chemical Properties

• Boiling Point: 318.8°Cat760mmHg
• Flash Point: 146.6°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.000353mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate(96507-72-1)
• EPA Substance Registry System: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate(96507-72-1)

Safety Data

• Hazardous Substances Data: 96507-72-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12ClNO3/c1-2-14-9(13)11-4-3-8(10)7(5-11)6-12/h6H,2-5H2,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 54903-50-3 4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 116118-98-0 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid 
• 116119-00-7 6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Efficient synthesis of 4- And 5-substituted 2-aminopyrimidines by coupling of β-Chlorovinyl Aldehydes and Guanidines

A general, practical, and simple synthesis of functionalized 2-aminopyrimidines starting from β-chlorovinyl aldehydes and amidines is reported. In the presence of potassium carbonate, various ketones have been efficiently transformed into the pyrimidine derivatives by a two-step sequence involving the Vilsmeier-Haack reaction followed by a condensation reaction with guanidines. The protocol is distinguished by operational simplicity, inexpensive reagents, and functional-group tolerance. In many cases, pure solid products can be obtained in high to excellent yields without using column chromatography. The synthetic value of the method was demonstrated by the efficient synthesis of steroidal pyrimidines and a precursor of the antitumor agents Imatinib and Mocetinostat.

A Straightforward Approach toward Multifunctionalized Pyridazines via Imination/Electrocyclization

A facile synthesis of functionalized 3-carbamide pyridazines starting from readily available chlorovinyl aldehydes and oxamic acid thiohydrazides via cascade imination/electrocyclization is reported. In the presence of p-toluenesulfuric acid, various ketones have been efficiently incorporated into the pyridazine derivatives through a two-step sequence involving a Vilsmeier-Haack reaction and imination. The synthetic value of this method has been demonstrated by efficient synthesis of steroidal pyridazines.

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.

Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: New selective ligands of the 5-HT7 receptor

The synthesis and the affinity for the 5-HT7 receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT7 receptor. Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles 5d and 5h are potent ligands for the 5-HT7 receptor, with high selectivity over the 5-HT2 receptor and other receptors. These compounds should be useful tools for clarifying the biological role of the 5-HT7 receptor.