Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate
CAS No.:96507-72-1
Molecular Formula:C9H12 Cl N O3
Molecular Weight:217.652
Hs Code.:2933399090
European Community (EC) Number:306-150-6
UNII:VGL944DWM8
DSSTox Substance ID:DTXSID80242284
Nikkaji Number:J382.887E
Wikidata:Q83125922
Mol file:96507-72-1.mol

Synonyms:96507-72-1;Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate;ethyl 4-chloro-5-formyl-3,6-dihydro-2H-pyridine-1-carboxylate;ethyl 4-chloro-5-formyl-3,6-dihydropyridine-1(2H)-carboxylate;EINECS 306-150-6;C9H12ClNO3;ethyl 4-chloro-5-formyl-1,2,3,6-tetrahydropyridine-1-carboxylate;VGL944DWM8;SCHEMBL978091;C9-H12-Cl-N-O3;DTXSID80242284;BMUCDCSKVFZPSS-UHFFFAOYSA-N;1(2H)-pyridinecarboxylic acid, 4-chloro-3-formyl-5,6-dihydro-, ethyl ester;AKOS025141900;Ethyl 4-chloro-3-formyl-5,6-dihydro-1(2H)-pyridinecarboxylate;Ethyl 4-chloro-3-formyl-5,6-dihydropyridine-1(2H)-carboxylate;4-Chloro-3-formyl-5,6-dihydro-1(2H)-pyridinecarboxylic acid ethyl ester

Suppliers and Price of Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate

Chemical Property:

Vapor Pressure:0.000353mmHg at 25°C
Boiling Point:318.8°Cat760mmHg
Flash Point:146.6°C
PSA：46.61000
Density:1.27g/cm³
LogP:1.47830
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:217.0505709
Heavy Atom Count:14
Complexity:275

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)N1CCC(=C(C1)C=O)Cl

Technology Process of Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate

There total 1 articles about Ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 96507-72-1
ethyl 4-chloro-3-formyl-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With trichlorophosphate;
DOI:10.1016/S0960-894X(02)00485-7

Reference yield: 57.0%

: 127719-64-6
N⁽¹⁾-(4-methoxyphenyl)-2-hydrazino-2-thioxoacetamide

: 96507-72-1
ethyl 4-chloro-3-formyl-5,6-dihydropyridine-1(2H)-carboxylate

: ethyl 1-((4-methoxyphenyl)carbamoyl)-7,8-dihydropyrido[3,4-d]pyridazine-6(5H)-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; Reflux;
DOI:10.1080/10426507.2016.1250759

Reference yield:

: 96507-72-1
ethyl 4-chloro-3-formyl-5,6-dihydropyridine-1(2H)-carboxylate

: 54903-50-3
4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N; pyridine

2: 50 percent aq. KOH

3: 83 percent / 3.5 N aq. KOH / Heating

4: 95 percent / 47 percent aq. HBr / Heating

With pyridine; potassium hydroxide; hydrogen bromide; triethylamine;
DOI:10.1016/S0960-894X(02)00485-7