- Synthesis and Determination of 10-Oxomorphine, a Decomposition Product of Morphine
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10-Oxomorphine, a decomposition product of morphine, was synthesized from 6-O-acetylcodeine, which was oxidized with chromic acid to 6-O-acetyl-10-hydroxycodeine.This substance was then oxidized with manganese dioxide to 6-O-acetyl-10-oxocodeine, which on hydrolysis and O-demethylation gave 10-oxomorphine.UV-, fluorimetric spectrometry, TLC and HPLC methods were used for determination of 10-oxomorphine.
- Proska, B.
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p. 687 - 688
(2007/10/02)
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