97073-72-8

Basic information

• Product Name: 4,7-dimethyl-5,6-dihydroxytryptamine
• Synonyms: 4,7-dimethyl-5,6-dihydroxytryptamine
• CAS NO: 97073-72-8
• Molecular Formula: C12H16N2O2
• Molecular Weight: 0
• Mol File: 97073-72-8.mol

Chemical Properties

• Boiling Point: 459.1°Cat760mmHg
• Flash Point: 231.4°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 4.77E-09mmHg at 25°C
• Refractive Index: 1.702
• CAS DataBase Reference: 4,7-dimethyl-5,6-dihydroxytryptamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-dimethyl-5,6-dihydroxytryptamine(97073-72-8)
• EPA Substance Registry System: 4,7-dimethyl-5,6-dihydroxytryptamine(97073-72-8)

Safety Data

• Hazardous Substances Data: 97073-72-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16N2O2/c1-6-9-8(3-4-13)5-14-10(9)7(2)12(16)11(6)15/h5,14-16H,3-4,13H2,1-2H3

Upstream product

• 60-27-5 creatinine 
• 97073-62-6 2-(5,6-Bis-benzyloxy-4,7-dimethyl-1H-indol-3-yl)-ethylamine 
• 97073-59-1 (5,6-Bis-benzyloxy-4,7-dimethyl-1H-indol-3-yl)-acetonitrile 

Relevant articles and documents

Molecular Mechanism of Action of 5,6-Dihydroxytryptamine. Synthesis and Biological Evaluation of 4-Methyl-, 7-Methyl-, and 4,7-Dimethyl-5,6-dihydroxytryptamines

The major mechanism by which the serotonin neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) expresses its neurodegenerative action may involve alkylation of biological nucleophiles by the electrophilic quinoid autoxidation products.To determine the relative importance of various sites on these autoxidation products toward alkylation we have rationally designed and synthesized 4-Me-5,6-DHT (16a), 7-Me-5,6-DHT (16b), and 4,7-Me2-5,6-DHT (16c).The indole nucleus of these analogues was constructed by the reductive cyclization of the corresponding 2,β-dinitrostyrenes, and the aminoethyl side chain was introduced via gramine methiodides.Redox data showed that all the analogues are more readily oxidized compared to 5,6-DHT.The biological activity was evaluated in differentiated neuroblastoma N-2a cells in culture.The order of inhibitory potency, as determined by measuring the inhibition of incorporation of thymidine into DNA, was 16c >> 16a > 5,6-DHT 16b.The order of affinity (expressed as IC50 values in μM) for serotonergic uptake as determined by measuring their inhibition of -5-HT uptake was 5,6-DHT (4) > 16c (20) > 16a (23) > 16b (52).The results of these studies established that these rationally designed C-methylated analogues of 5,6-DHT are suitable probes for elucidating the molecular mechanism of action of 5,6-DHT.