60-27-5 Usage
Description
Creatinine is together with urea, the most widely known "uremic toxin", and is usually assessed when- ever a reduction in kidney function is suspected. This is mainly because creatinine evaluation is cheap, widely accessible and relatively well reflects the renal function. It also forms the basis for estimation of estimated glomerular filtration rate (eGFR) and thus is a major component of all principal eGFR equations.Creatinine, which is nonenzymatically produced from the creatine pool in skeletal muscle, but is also to some extent generated from exogenous creatine present in meat, is the major guanidine compound retained in patients with diminished glomerular filtration rate. Creatinine is routinely determined in plasma or serum as a measure of impairment of renal function and it might be expected that a variety of uremic symptoms correlate with the plasma creatinine level; this does not, however, necessarily imply a causal relationship. In fact, high serum creatinine levels correlate with low mortality in HD patients, presumably because the creatinine generation rate reflects the size of the muscle mass. Creatinine seems to be relatively nontoxic. Large amounts of creatinine have been fed to healthy subjects without any adverse effects and animals also tolerate large doses.
Chemical Properties
white powder
Uses
Different sources of media describe the Uses of 60-27-5 differently. You can refer to the following data:
1. metabolic enhancer
2. Creatinine is the end product of creatine catabolism. Creatinine is a normal constituent of urine. Also found together with creatine in muscle tissues and blood. Creatinine is found in all soils and i
n grain seeds and other vegetable matter as well as in certain fish and in crab meat extract.
3. Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function. It is a substrate for creatininase.
Definition
ChEBI: A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.
Biological Functions
Creatinine is a byproduct of a chemical compound called creatine, which helps muscles get the energy that they need. As a waste product, creatinine is filtered out of the blood by the kidneys and removed from the body in urine.A creatinine test measures the amount of this chemical in either the blood or urine. Creatinine levels can provide an indication of how well the kidneys are working.Creatinine may be measured alone or included in a panel of tests that include other compounds found in the urine or blood.https://labtestsonline.org/tests/creatininehttps://www.kidney.org/atoz/content/what-creatinine
General Description
Creatinine is a breakdown product formed by the degradation of creatine phosphate from muscles. The kidneys extract creatinine from the body by filtering almost all of it from the blood and excreting it in the urine. Serum creatinine is the most commonly used indicator for renal functioning. In chemical synthesis, creatinine is used as a heterocyclic nitrogenous compound that produces electron-rich and highly basic creatinine derivatives.
Purification Methods
Likely impurities are creatine and ammonium chloride. Dissolve it in dilute HCl, then neutralise with ammonia. Recrystallise it from H2O by adding excess of Me2CO. The picrate crystallises from 23volumes of boiling H2O and has m 220-221o(dec). [King J Chem Soc 2377 1930, Beilstein 25 III/IV 2543.]
Check Digit Verification of cas no
The CAS Registry Mumber 60-27-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60-27:
(4*6)+(3*0)+(2*2)+(1*7)=35
35 % 10 = 5
So 60-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/p+1
60-27-5Relevant articles and documents
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Hongo
, p. 279,289 (1935)
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Lundquist
, p. 98 (1947)
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A preparation method of creatinine
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Paragraph 0014; 0028-0042; 0055; 0056, (2019/03/31)
The invention belongs to the technical field of chemical synthesis, in particular relates to a preparation method of creatinine, the method to creatine as the starting material, and containing 2 - 5 carbon of the lower saturated fatty acid reaction. The method of environmental protection, without by-product to produce, almost zero-emission, without refining can be directly used for cardiac muscle protective drug creatine phosphate sodium synthetic.
METHOD FOR PREPARING CREATINE FATTY ESTERS, CREATINE FATTY ESTERS THUS PREPARED AND USES THEREOF
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Page/Page column 26, (2014/02/16)
The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group and of formula R'-OH in which R' represents a hydrocarbon radical containing at least 4 carbon atoms. The present invention also concerns particular creatine fatty esters or derivative thereof and medical uses thereof.
