Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength
A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.
Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-Fused area and the difference in spectra, photochemistry and photobiological activity
Novel five- and six-membered thiocyclic-fused naphthalimide hydroperoxides (7, 8) as photonucleases were designed, synthesized via unusual isomerization in Pschorr cyclization and photooxygenation. The five-membered 7 was able to induce single-strand nick