2-Fluoroformycin and 2-Aminoformycin. Synthesis and Biological Activity
Syntheses of 2-fluoroformacin pyrimidine> (2b) and 2-aminoformacin pyrimidine> (2c) are described.Cytotoxicity data are given for 2b and 2c alone as well as with added pentostatin.Kinetic parameters for adenosine deaminase are also provided. 2-Fluoroformycin, although a much poorer substrate for adenosine deaminase than formycin A, is not nearly as cytotoxic to cells in culture.
Secrist, John A.,Shortnacy, Anita T.,Montgomery, John A.