Journal of Medicinal Chemistry p. 1740 - 1742 (1985)
Update date:2022-08-05
Topics:
Secrist, John A.
Shortnacy, Anita T.
Montgomery, John A.
Syntheses of 2-fluoroformacin <7-amino-5-fluoro-3-(β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine> (2b) and 2-aminoformacin <5,7-diamino-3-(β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine> (2c) are described.Cytotoxicity data are given for 2b and 2c alone as well as with added pentostatin.Kinetic parameters for adenosine deaminase are also provided. 2-Fluoroformycin, although a much poorer substrate for adenosine deaminase than formycin A, is not nearly as cytotoxic to cells in culture.
View MoreHangzhou Pharma & Chem Co.,Ltd.
Contact:+86-571-87040515
Address:No,139Qingchun Rd
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.
Contact:+86-186-02659358
Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
website:http://www.apeptides.com/en/
Contact:+86-21-60871011
Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Zhejiang Chemicals Import & Export Corporation
Contact:86-571-87043088
Address:No.37,Qingchun Road,Hangzhou,China
Taizhou KEDE Chemical.Co.,Ltd.
Contact:86-576-84613060
Address:Jiangkou Chemical Zoon
Doi:10.1021/ja00215a032
(1988)Doi:10.1021/jo00219a064
(1985)Doi:10.1021/jo00225a008
(1985)Doi:10.1021/jo01342a052
(1966)Doi:10.1021/ja00311a085
(1985)Doi:10.1080/00397919308009835
(1993)
