- ARSENIC COMPLEXES FOR POTENTIAL DIAGNOSTIC APPLICATIONS
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The present invention provides radioactive arsenic complex useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.
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Paragraph 0110-0111
(2014/03/24)
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- Kinetic method for determination of trace amounts of protein based on its inhibitive effect on potassium periodate-(dibromo-p-sulfonic acid arsenazo) indicator reaction
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A novel kinetic spectrophotometric method for the determination of protein is based on the inhibitive effect of bovine serum albumin (BSA) on the oxidation reaction of dibromo-p-sulfonic acid arsenazo (DBS-ASA) by potassium periodate in the medium of CH2ClCOOHCH3COONH4. The maximum absorption peak of BSA-(DBS-ASA)-KIO4 system is located at 530 nm. The absorbance difference (δA) is well linearly related with the concentration of bovine serum albumin over the rage of 2.5-90.0 μg/mL of solution and fitted the equation: δA = 0.01091C + 0.0646 (C: μg/mL), with a correlation coefficient γ = 0.9941. The detection limit of the method was 0.48 μg/mL. The method has been successfully used in the determination of the total content of protein in egg white and the relative standard deviation of 15 determinations were less than 5 %. The recovery of standard addition of the method was over the range of 100.1-101.2 %.
- Zhai, Qing-Zhou,Yu, Hui,Hu, Wei-Hua,Zhu, Peng-Hui
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experimental part
p. 4072 - 4078
(2012/01/13)
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- Substituted phenylarsonic acids; structures and spectroscopy
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Full NMR and ESI-MS spectra, and differential scanning calorimeter data are presented for 15 substituted phenylarsonic acids, including two new fluoro-substituted examples. X-ray crystal structure determinations of five examples (phenylarsonic acid and the 4-fluoro-, 4-fluoro-3-nitro-, 3-amino-4-hydroxy- and 3-amino-4-methoxy-substituted derivatives) were determined and the H-bonding crystal-packing patterns analysed.
- Lloyd, Nicholas C.,Morgan, Hugh W.,Nicholson, Brian K.,Ronimus, Ron S.
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p. 2443 - 2450
(2008/09/20)
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- Studies on the air oxidation of some arsenic(III) compounds
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The air oxidation of As(III) oxides [(PhAsO)x and Ph 2As-O-AsPh2] and thioesters [Ph-As(SPh)2, Ph2As-SPh Me-As(SPh)2, Me2As-SPh], in chloroform and in methanol was studied. The air oxidation in chloroform was faster probably because the solubility of dioxygen is greater than in methanol, and it is favored by the electron-withdrawing phenyl groups bound to As(III). The products obtained were the arsonic or arsinic acids and diphenyl disulfide. In one case, diphenyl disulfide and thiophenol were produced. The results can be rationalized by assuming first hydrolysis of the As(III) compounds to arsonous or arsinous acids followed by their oxidation to arsonic and arsinic acids, which should involve the binding of dioxygen to As(III). The other hypothesis assumes first the binding of dioxygen to As(III) of these oxides and thioesters followed by the decomposition of the adducts. The binding of the ground state dioxygen to As(III) may have biochemical implications for toxicity or chemotherapy of arsenic(III) compounds. Copyright Taylor & Francis Group, LLC.
- Sideris, Theodore D.,Ioannou, Panayiotis V.
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p. 751 - 762
(2007/10/03)
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- SYNTHESIS AND PROPERTIES OF ARYLARSONIC ACIDS
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1.A number of arylarsonic acids with various substituents in the ortho, meta, and para positions in the benzene ring were synthesized from diazonium salts by the Bart reaction; the products were characterized by their IR spectra. 2.By the DTA method it was established that arylarsonic acid molecules were linked together through hydrogen bonds to form oligomeric associated forms. 3.The IR spectra of arylarsonic acids confirm the presence in them of strong hydrogen bonds through which they are able to undergo association into two forms differing in the symmetry of the d isposition of the As=O bonds.A form which gives a C band arises if the arsonyl oxygen participates in the formation of two hydrogen bonds simultaneously, as a result of which the molecules are linked together to form endless chains and columns.In the other form there are probably cyclic dimers with intermolecular H bonds.
- Yambushev, F. D.,Kovyrzina, V>,P.,Shagidullin, R. R.,Gorchakova, L. A.,Fedotov, B. G.,et al.
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p. 1919 - 1926
(2007/10/02)
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