98-05-5

Usage

Uses

Used in Chemical Analysis:
Phenylarsonic acid is used as a reagent for the selective determination of tetravalent metals of group IV of the periodic system, such as zirconium(IV), hafnium(IV), and titanium(IV), in the presence of many other metals. It forms water-insoluble complexes with these metals, which can be transformed by ignition to the corresponding metal oxides and weighed for analysis.
Used in Mineral Analysis:
In strong mineral acidic media, phenylarsonic acid forms water-insoluble precipitates with zirconium and hafnium only, allowing for their selective determination. In highly concentrated acetic acid solution, the thorium phenylarsonate complex is also precipitated, enabling the separation of thorium from rare earth metals.
Used in Analytical Chemistry:
Phenylarsonic acid is used for the determination of zirconium, as it provides satisfactory results in the presence of alkaline earth metals, iron, aluminum, manganese, cobalt, nickel, copper, zinc, and bismuth. It is frequently utilized in practice for this purpose.
Overall, phenylarsonic acid is a versatile reagent in various fields of analysis, particularly in the selective determination and separation of specific metal ions.

Reactivity Profile

PHENYLARSONIC ACID emits poisonous fumes of arsenic when heated to decomposition. [EPA, 1998].

Health Hazard

PHENYLARSONIC ACID is a deadly poison. (Non-Specific -- Arsenic Compounds) Chronic exposure to arsenic compounds can cause dermatitis and digestive disorders. Renal damage may develop.

Fire Hazard

PHENYLARSONIC ACID emits poisonous fumes of arsenic when heated to decomposition.

Safety Profile

A deadly poison by ingestion andintravenous routes. When heated to decomposition it emits toxic fumes of As.

Potential Exposure

This material is used as an analytical reagent for tin.

Shipping

UN3280 Organoarsenic compound, liquid, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. Potential Inhalation Hazard (Special Provision 5).

Purification Methods

Crystallise it from H2O (3mL/g) between 90o and 0o. Alternatively dissolve 600g of the acid in 500mL of boiling H2O, add 20g of Norite, filter hot, cool, filter off the crystals and dry them. On heating at ~154-160o it is converted to the anhydride. [Bullard & Dickery Org Synth Coll Vol II 494 1943, for the 4-nitro derivative see Ruddy & Starkey Org Synth Coll Vol III 665 1955, Beilstein 16 H 868, 16 I 448, 16 II 457, 16 III 1057, 16 IV 1183.]

InChI:InChI=1/C6H7AsO3/c8-7(9,10)6-4-2-1-3-5-6/h1-5H,(H2,8,9,10)

Upstream product

• 13904-70-6 phenyl-arsonic acid-dichloride 
• 4519-32-8 Diphenyldiarsenic acid 
• 822-65-1 phenylarsane 
• 861318-71-0 3,6-dimethyl-2,5-diphenyl-[1,4,2,5]dioxadiarsinane 
• 7697-37-2 nitric acid 
• 861294-12-4 bis-(1-hydroxy-ethyl)-phenyl-arsine 
• 56-23-5 tetrachloromethane 
• 57965-37-4 (Z)-benzenediazo hydroxide; sodium-salt 
• 84110-40-7 Dihydroxy-isobutyl-boran 
• 328558-04-9 4-methyl-2-phenyl-1,3-dioxa-2-arsenacyclohexane 2-oxide 
• 29181-03-1 tetrachloro-phenyl-arsorane 
• 2684-02-8 benzenediazonium 
• 98-50-0 p-aminophenylarsonic acid 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 27491-99-2 2,2,3,3,7,7,8,8-Octamethyl-5-phenyl-1,4,6,9-tetraoxa-5-arsaspiro<4.4>nonan 
• 32049-50-6 3,3,8,8-tetramethyl-5-phenyl-1,4,6,9-tetraoxa-5λ⁵-arsa-spiro[4.4]nonane-2,7-dione 
• 650-44-2 tetrafluoro-phenyl-arsorane 
• 637-03-6 phenylarsine oxide 
• 696-28-6 dichlorophenylarsine 
• 6380-34-3 phenyldiiodoarsine 
• 618-07-5 3-nitrophenylarsonic acid 
• 108-90-7 chlorobenzene 
• 822-65-1 phenylarsane 
• 18880-74-5 phenyl-arsonic acid bis-(chloro-diphenyl-silanyl ester) 
• 53720-59-5 dipropyl phenylarsonate 
• 16216-37-8 Phenylarsonsaeure-bis <2-chloraethylester> 
• 37907-80-5 phenyl-arsonic acid diethyl ester 
• 65190-62-7 phenyl-arsonic acid dimethyl ester 

Relevant academic research and scientific papers

ARSENIC COMPLEXES FOR POTENTIAL DIAGNOSTIC APPLICATIONS

The present invention provides radioactive arsenic complex useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.

Kinetic method for determination of trace amounts of protein based on its inhibitive effect on potassium periodate-(dibromo-p-sulfonic acid arsenazo) indicator reaction

A novel kinetic spectrophotometric method for the determination of protein is based on the inhibitive effect of bovine serum albumin (BSA) on the oxidation reaction of dibromo-p-sulfonic acid arsenazo (DBS-ASA) by potassium periodate in the medium of CH2ClCOOHCH3COONH4. The maximum absorption peak of BSA-(DBS-ASA)-KIO4 system is located at 530 nm. The absorbance difference (δA) is well linearly related with the concentration of bovine serum albumin over the rage of 2.5-90.0 μg/mL of solution and fitted the equation: δA = 0.01091C + 0.0646 (C: μg/mL), with a correlation coefficient γ = 0.9941. The detection limit of the method was 0.48 μg/mL. The method has been successfully used in the determination of the total content of protein in egg white and the relative standard deviation of 15 determinations were less than 5 %. The recovery of standard addition of the method was over the range of 100.1-101.2 %.

Substituted phenylarsonic acids; structures and spectroscopy

Full NMR and ESI-MS spectra, and differential scanning calorimeter data are presented for 15 substituted phenylarsonic acids, including two new fluoro-substituted examples. X-ray crystal structure determinations of five examples (phenylarsonic acid and the 4-fluoro-, 4-fluoro-3-nitro-, 3-amino-4-hydroxy- and 3-amino-4-methoxy-substituted derivatives) were determined and the H-bonding crystal-packing patterns analysed.

Studies on the air oxidation of some arsenic(III) compounds

The air oxidation of As(III) oxides [(PhAsO)x and Ph 2As-O-AsPh2] and thioesters [Ph-As(SPh)2, Ph2As-SPh Me-As(SPh)2, Me2As-SPh], in chloroform and in methanol was studied. The air oxidation in chloroform was faster probably because the solubility of dioxygen is greater than in methanol, and it is favored by the electron-withdrawing phenyl groups bound to As(III). The products obtained were the arsonic or arsinic acids and diphenyl disulfide. In one case, diphenyl disulfide and thiophenol were produced. The results can be rationalized by assuming first hydrolysis of the As(III) compounds to arsonous or arsinous acids followed by their oxidation to arsonic and arsinic acids, which should involve the binding of dioxygen to As(III). The other hypothesis assumes first the binding of dioxygen to As(III) of these oxides and thioesters followed by the decomposition of the adducts. The binding of the ground state dioxygen to As(III) may have biochemical implications for toxicity or chemotherapy of arsenic(III) compounds. Copyright Taylor & Francis Group, LLC.

SYNTHESIS AND PROPERTIES OF ARYLARSONIC ACIDS

1.A number of arylarsonic acids with various substituents in the ortho, meta, and para positions in the benzene ring were synthesized from diazonium salts by the Bart reaction; the products were characterized by their IR spectra. 2.By the DTA method it was established that arylarsonic acid molecules were linked together through hydrogen bonds to form oligomeric associated forms. 3.The IR spectra of arylarsonic acids confirm the presence in them of strong hydrogen bonds through which they are able to undergo association into two forms differing in the symmetry of the d isposition of the As=O bonds.A form which gives a C band arises if the arsonyl oxygen participates in the formation of two hydrogen bonds simultaneously, as a result of which the molecules are linked together to form endless chains and columns.In the other form there are probably cyclic dimers with intermolecular H bonds.