- Haloacetylated Enol Ethers. 8 [12]. Reaction of β-Alkoxyvinyl Trihalomethyl Ketones with Guanidine Hydrochloride. Synthesis of 4-Trihalomethyl-2-Aminopyrimidines
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In this work the results of the reaction of β-alkoxyvinyl trihalomethyl ketones 1, 2a-e, with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried out, 4-trihalomethyl-2-amino pyrimidines, β-alkoxyvinyl carboxylic acids, or β-acetal carboxylic esters were obtained.
- Zanatta, Nilo,Cortelini, Maria De F. M.,Carpes, Marcos J. S.,Bonacorso, Helio G.,Martins, Marcos A. P.
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p. 509 - 513
(2007/10/03)
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- A Convenient Synthetic Method for β-Alkoxy- and β-Phenoxyacrylic Acids and 3,4-Dihydro-2H-pyran-5- and 2,3-Dihydrofuran-4-carboxylic Acids
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trans-β-Trihaloacetylvinyl ethers 1 are easily hydrolyzed by wet potassium hydroxide in benzene, yielding the corresponding acids 2 in excellent yields.This synthetic method also can be applicable to cyclic vinyl ethers 3 and 5 to yield 4 and 6 in high yi
- Hojo, Masaru,Masuda, Ryoichi,Sakaguchi, Syuhei,Takagawa, Makoto
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p. 1016 - 1017
(2007/10/02)
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