PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY
A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.
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Paragraph 0799; 0800; 0798
(2017/07/05)
Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis
The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase. The Royal Society of Chemistry.
Wyatt, Emma E.,Galloway, Warren R. J. D.,Thomas, Gemma L.,Welch, Martin,Loiseleur, Olivier,Plowright, Alleyn T.,Spring, David R.