- Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1 H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors
-
A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in 2009. To develop more potential SDH inhibitors, we designed and synthesized a novel se
- Wu, Zhibing,Park, Hyung-Yeon,Xie, Dewen,Yang, Jingxin,Hou, Shuaitao,Shahzad, Nasir,Kim, Chan Kyung,Yang, Song
-
p. 1214 - 1223
(2021/02/06)
-
- SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS
-
Disclosed are compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is formula (II) Q is a substituted 5-membered monocyclic heteroaryl group; W is CH2, O, or NH; and R1, R2, R3, R4, R5, R6, m, n, t, and x are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
- -
-
Page/Page column 158
(2011/02/24)
-
- Pyrazole-amides and sulfonamides as sodium channel modulators
-
Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.
- -
-
Page/Page column 13
(2010/02/10)
-
- Pyrazole-amides and sulfonamides as sodium channel modulators
-
Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.
- -
-
-