Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction
Spergualin is a natural product that exhibits immunosuppressive, anti-tumor and anti-bacterial activities. Its derivatives, such as 15-deoxyspergualin (15-DSG), have been clinically approved for acute allograft rejection. However, the reported syntheses a
Evans, Christopher G.,Smith, Matthew C.,Carolan, James P.,Gestwicki, Jason E.
p. 2587 - 2590
(2011/06/20)
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