- ON THE MECHANISM OF HYDROGEN TRANSFER BY NICOTINAMIDE COENZYMES AND SOME DEHYDROGENASES
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The course of the oxidation of 2,2-dimethylcyclopropylmethanol and 2,2,3,3-tetramethylcyclopropylmethanol by horse liver alcohol dehydrogenase and NAD+ has been investigated.In neither case were ring opened products detected which, in agreement with previous observations, provides no evidence for the intermediacy of radicals in these reactions.The stability of several substituted cyclopropyl-alkyl radicals has been investigated by e.s.r. spectroscopy and the results are discussed with respect to cyclopropane-containing probes of the mechanism of oxidation of lactate dehydrogenase.
- Laurie, David,Lucas, Edward,Nonhebel, Derek C.,Suckling, Colin J.
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- Stereodivergence in the Ireland-Claisen Rearrangement of α-Alkoxy Esters
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A systematic investigation into the Ireland-Claisen rearrangement of α-alkoxy esters is reported. In all cases, the use of KN(SiMe3)2 in toluene gave rearrangement products corresponding to a Z-enolate intermediate with excellent diastereoselectivity, presumably because of chelation control. On the other hand, chelation-controlled enolate formation could be overcome for most substrates through the use of lithium diisopropylamide (LDA) in tetrahydrofuran (THF).
- Podunavac, Ma?a,Lacharity, Jacob J.,Jones, Kerry E.,Zakarian, Armen
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supporting information
p. 4867 - 4870
(2018/08/24)
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- Anesthetic compounds and related methods of use
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Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.
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Page/Page column 66
(2015/11/09)
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- ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE
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Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.
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Paragraph 00203
(2013/07/25)
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