- CYTOKINE INHIBITORS
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Provided is a compound of Formula (I): and/or at least one pharmaceutically acceptable salt thereof. Also provided are a method of inhibiting the activity of at least one protein chosen from TNFα, IL-1β, NF-κB, IL-10 and iNOS, a method of decreasing a lev
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- CYTOKINE INHIBITORS
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A compound of Formula I: Each variable is defined in the specification. This invention relates to a method of decreasing a level of a cytokine (e.g., TNFα or interlukine such as IL-1β) in a subject with a compound of Formula I. It also relates to a method
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Page/Page column 29
(2009/05/28)
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- Improving implant materials by coating with nonpeptidic, highly specific integrin ligands
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Giving cells some stick: Osteoblast adhesion to titanium, a common material for implants, is stimulated by coating with an optimized and highly specific nonpeptidic ligand for the αvβ3 integrin (see picture). This new technology is advantageous to conventional coating by peptides or proteins in many practical aspects (selectivity and activity, stability against enzymatic degradation, sterilization, costs).
- Dahmen, Claudia,Auernheimer, Joerg,Meyer, Axel,Enderle, Anja,Goodman, Simon L.,Kessler, Horst
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p. 6649 - 6652
(2007/10/03)
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