A general effective organocatalyzed synthesis of enantioenriched morphans with up to 92% ee was developed. The morphan scaffold was constructed in a one-pot tandem asymmetric organocatalyzed Michael addition followed by a domino Robinson annulation/aza-Michael intramolecular reaction sequence from easily available starting materials.
Bradshaw, Ben,Parra, Claudio,Bonjoch, Josep
supporting information
p. 2458 - 2461
(2013/06/27)
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