- INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES
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Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
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Paragraph 00173-00175
(2021/12/28)
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- SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE
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The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.
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- Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)
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The invention discloses substituted heteroaryl compounds and compositions thereof and their use. The compounds of formula (I) compound or type shown in (I) a compound represented by stereo isomers, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The invention also provides a pharmaceutical composition, the compounds and pharmaceutical compositions can be regulated protein kinase, particularly Aurora kinase and JAK kinase activity, for the prevention, treatment, treatment and reduce protein kinase, in particular JAK kinase activity mediated diseases or disorders. (by machine translation)
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- BROMINATION OF 1,2-DIMETHYLBENZIMIDAZOLE WITH N-BROMOSUCCINIMIDE
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The reaction of 1,2-dimethylbenzimidazole with N-bromosuccinimide was studied under conditions of free-radical substitution.The influence of the reactant ratio and the mode of introduction of the brominating agent on the course of the reaction was investigated.It was found that bromination of 1,2-dimethylbenzimidazole with excess N-bromosuccinimide in the presence of benzoyl peroxide gives polybromoalkyl and polybromoaryl derivatives.
- Kuz'minykh, K. S.,Dumpis, M. A.
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p. 1310 - 1313
(2007/10/02)
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