- Thienopyrimidine compound and medical applications thereof
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The present invention relates to a thienopyrimidine-containing compound represented by a general formula (I), a pharmaceutically acceptable salt, a solvate and a prodrug thereof, wherein the substituents R1, R2, R3, R4, R5 and Q are defined in the specifi
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Paragraph 0114; 0117
(2020/06/17)
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- Basic Ionic Liquid [bmIm]OH-Mediated Gewald Reaction as Green Protocol for the Synthesis of 2-Aminothiophenes
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A simple, efficient, and environmental friendly procedure was developed based on the Gewald reaction for the synthesis of 2-aminothiophenes using a basic ionic liquid [bmIm]OH as both catalyst and solvent. Besides being a green protocol, the method offers advantages of successful synthesis of a variety of alkyl, aryl, alkoxy, and alkylamino-2-aminothiophenes in good yields.
- Kaki, Venkata Rao,Akkinepalli, Raghuram Rao,Deb, Pran Kishore,Pichika, Mallikarjuna Rao
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p. 119 - 126
(2015/10/20)
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- Thiophene derivatives
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The novel compound of the general formula I STR1 where X is fluorine, chlorine, bromine, SO2 Y or unsubstituted or substituted hydroxyl or mercapto, Y is alkyl, alkenyl, cycloalkyl, aralkyl, aryl, chlorine or unsubstituted or substituted hydrox
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- Trialkylamine salts of 3-chloro-1,1-dicyano-2-hydroxy-1-propene and preparation of 2-amino-4-chloro-3-cyano-5-formylthiophene
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Trialkylamine salts of 3-chloro-1,1-dicyano-2-hydroxy-1-propene, where the trialkylamine has from 10 to 24 carbon atoms, a process for their preparation from malononitrile, chloroacetyl chloride, and a trialkylamine, and a process for the preparation of 2-amino-4-chloro-3-cyano-5-formylthiophene in which a trialkylamine salt of 3-chloro-1,1-dicyano-2-hydroxy-1-propene is cyclized with hydrogen sulfide or another sulfide and treated with a mixture of N,N-dimethylformamide and phosphoryl chloride, and the product is hydrolyzed by acid without being isolated previously.
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- Preparation of aminothiophene derivatives
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Abstract of the Disclosure: Aminothiophene derivatives of the formula I STR1 where R is unsubstituted or substituted C1 -C8 -alkyoxycarbonyl, unsubstituted or substituted carbamyl or cyano, are prepared by a process in which a compound of the formula II where R has the above meanings, is reacted in water with a base and simultaneously or subsequently with a haloacetyl halide, and the product is then reacted with hydrogen sulfide or a water-soluble sulfide.
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