- Comments on a New Simple Route to N-Substituted 2-Aminoethylphosphonic Acids. A Reinvestigation
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A recent article[11] reported a new route to 2-aminoethylphosphonic acid and its N-alkyl derivatives by ammonolysis and aminolysis of 2-chloroethylphosphonic acid. Attempts to reproduce these reactions failed to give aminophosphonic acids and led only to unreacted amine and phosphates with evolution of ethylene.
- Soroka, Miroslaw,Stochaj, Monika
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- Dealkylation of dialkyl phosphonates with boron tribromide
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Boron tribromide cleanly and quantitatively converts dimethyl-, diethyl-, diisopropyl-, and ditertiobutyl phosphonates RP(O)(OR')2 into the corresponding phosphonic acids RP(O)(OH)2 via methanolysis. The use of boron tribromide is compatible with a variety of functionalities in the R group.
- Gauvry,Mortier
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p. 553 - 554
(2007/10/03)
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- AN APPROACH TOWARDS THE FORMATION OF AN ESTER BOND BETWEEN THE PRIMARY HIDROXYL OF A β-D-GALACTOPYRANOSIDE AND 2-AMINOETHYLPHOSPHONIC ACID AND ITS N-METHYL SUBSTITUTED DERIVATIVES
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An expeditious method for the preparation of the phosphonylating reagent 2-bromo-ethylphosphonic acid is presented.The latter compound as well as salicylchlorophosphite proved to be suitable for the synthesis of methyl O-6-(2'-aminoethyl-phosphonyl)-β-D-g
- Dreef, C. E.,Valentijn, A. R. P. M.,Vroom, E. de,Marel, G. A. van der,Boom, J. H. van
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p. 1199 - 1202
(2007/10/02)
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- Phosphocholine derivatives having antihypertensive action
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Phosphocholine derivatives and compositions are described which are useful as hypotensive agents and in the treatment of hypertension in warm-blooded animals.
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- Synergistic herbicidal compositions
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Synergistic herbicidal activity is displayed by compositions comprising the following two components: (a) a pyrrolidone of the formula STR1 in which X is selected from the group consisting of hydrogen, chlorine and methyl; Y is selected from the group consisting of hydrogen, chlorine and bromine; Z is selected from the group consisting of chlorine and bromine; R1 is selected from the group consisting of hydrogen and C1 -C4 alkyl; R2 is selected from the group consisting of hydrogen, halogen, C1 -C4 alkyl, acetyl, trifluoromethyl, nitro, cyano, C1 -C4 alkoxy, C1 -C4 alkylthio, C1 -C4 alkylsulfinyl, C1 -C4 alkylsulfonyl, trifluoromethylsulfinyl, trifluoromethylsulfonyl, pentafluoropropionamido, and 3-methylureido; and R3 is selected from the group consisting of hydrogen, C1 -C4 alkyl, chlorine and trifluoromethyl; and (b) a phosphonic acid of the formula STR2 in which R4 is selected from the group consisting of C1 -C4 alkyl, C1 -C4 haloalkyl, and --CH2 NHCH2 COOH, at a weight ratio of (a) to (b) of from about 0.1:1 to about 20:1.
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- The Dealkylation of Phosphate and Phosphonate Esters by Iodotrimethylsilane: A Mild and Selective Procedure
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Iodotrimethylsilane transforms alkyl esters of phosphorus oxyacids into their corresponding trimethylsilyl esters and alkyl iodide.The reaction is rapid and quantitative at room temperature.The reagent has no effect on aryl phosphate ester functions or upon alkyl carboxylate, ether, bromoalkane, vinyl, and ethynyl functions under the conditions employed for transesterification.The trimethylsilyl esters can be isolated by distillation or solvolysed without purification using methanol or water to afford dealkylated phosphate and phosphonate species.Selective monodealkylation of dialkyl phosphonates cannot be achieved using only one equivalent of the reagent, wich leads to the formation of mixed products.
- Blackburn, G. Michael,Ingleson, David
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p. 1150 - 1153
(2007/10/02)
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