100004-77-1

Basic information

• Product Name: 2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE
• Synonyms: 2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE
• CAS NO: 100004-77-1
• Molecular Weight: 199.252
• Mol File: 100004-77-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE(100004-77-1)
• EPA Substance Registry System: 2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE(100004-77-1)

Safety Data

• Hazardous Substances Data: 100004-77-1(Hazardous Substances Data)

Usage

Pyridine derivative

This compound is derived from pyridine, a heterocyclic aromatic compound with a six-membered ring structure containing five carbon atoms and one nitrogen atom.

Methoxy and methyl groups

The compound features a methoxy group (-OCH3) attached to the 2nd position of the phenyl ring and a methyl group (-CH3) attached to the 4th position of the phenyl ring.

Common uses

2-(2-Methoxyphenyl)-4-methyl-pyridine is frequently used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It also serves as an intermediate in the production of various fine chemicals.

Physical properties

The compound is a white to pale yellow crystalline solid.

Melting point

around 74-76°C

Boiling point

291-297°C

Solubility

2-(2-Methoxyphenyl)-4-methyl-pyridine is soluble in organic solvents but remains insoluble in water.

Safety precautions

Proper safety measures and procedures should be followed when handling and storing 2-(2-Methoxyphenyl)-4-methyl-pyridine to minimize potential hazards.

Upstream product

• 4926-28-7 2-Bromo-4-picoline 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 3678-62-4 2-chloro-4-picoline 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 67-56-1 methanol 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 863988-32-3 2-(4-methylpyridin-2-yl)phenol 

Relevant articles and documents

Copper-catalyzed fluorination of 2-pyridyl aryl bromides

Copper(i)-catalyzed cross-coupling of aryl halides is the subject of extensive interest in synthetic chemistry, but the related catalytic fluorination is unsuccessful. Herein, we have developed a novel copper-catalyzed fluorination of aryl bromides using AgF as the fluorine source. In this transformation a pyridyl directing group is essential for successful catalytic fluorination. A XANES/EXAFS study indicated that the presence of the pyridyl group is essential to stabilize the Cu(i) species and accelerate oxidative addition of the aryl bromide. Further mechanistic studies implicated a Cu(i/iii) catalytic cycle in this Cu(i)-catalyzed fluorination, and final aryl C-F bond formation possibly proceeds through an irreversible reductive elimination of the ArCu(iii)-F species. This rare report of catalytic fluorination by a copper catalyst provides a valuable foundation for further development of Cu(i)-catalyzed fluorination of aryl halides.

Synthesis of Chemically and Configurationally Stable Monofluoro Acylboronates: Effect of Ligand Structure on their Formation, Properties, and Reactivities

The recent disclosures of two classes of acylborons, potassium acyltrifluoroborates (KATs) and N-methyliminodiacetyl (MIDA) acylboronates, demonstrated that certain acylboron species can be both remarkably stable and uniquely reactive. Here we report new classes of ligands for acylboronates that have a significant influence on the formation, properties, and reactivities of acylboronates. Our systematic investigations identified a class of neutral, monofluoroboronates that can be prepared in a one step, gram-scale fashion from readily accessible KATs. These monofluoroboronates are stable to air, moisture, and silica gel chromatography and can be easily handled without any special precautions. X-ray crystallography, NMR spectroscopy, and HPLC studies showed that they are tetravalent, configurationally stable B-chiral acylboronates. Significantly, the ligands on the boronate allow for fine-tuning of the properties and reactivity of acylboronates. In amide-forming ligation with hydroxylamines under aqueous conditions, a considerable difference in reactivity was observed as a function of ligand structure. The solid-state structures suggested that subtle steric and conformational factors modulate the reactivities of the acylboronates.

Synthesis in 3 Azafluorene Group. Part-III

The Hey-Elks route to arylated pyridines has been utilised in the synthesis of 3-azafluorenes.The pyrido-coumarin (23) and the related chromene (24) have been synthesised.