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Cas Database

100004-77-1

100004-77-1

Identification

  • Product Name:2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE

  • CAS Number: 100004-77-1

  • EINECS:

  • Molecular Weight:199.252

  • Molecular Formula:C13H13NO

  • HS Code:

  • Mol File:100004-77-1.mol

Synonyms:2-(2-METHOXYPHENYL)-4-METHYL-PYRIDINE

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 5 Articles be found

α1-Adrenoceptor agonists: The identification of novel α1A subtype selective 2′-heteroaryl-2-(phenoxymethyl)imidazolines

Bishop, Michael J.,Barvian, Kevin A.,Berman, Judd,Bigham, Eric C.,Garrison, Deanna T.,Gobel, Michael J.,Hodson, Stephen J.,Irving, Paul E.,Liacos, James A.,Navas, Iii, Frank,Saussy Jr., David L.,Speake, Jason D.

, p. 471 - 475 (2007/10/03)

Novel 2′-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human α1-adrenoceptors in vitro. The nature of the 2′-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. α1A Subtype selective agonists have been identified.

Synthesis of Chemically and Configurationally Stable Monofluoro Acylboronates: Effect of Ligand Structure on their Formation, Properties, and Reactivities

Noda, Hidetoshi,Bode, Jeffrey W.

supporting information, p. 3958 - 3966 (2015/04/14)

The recent disclosures of two classes of acylborons, potassium acyltrifluoroborates (KATs) and N-methyliminodiacetyl (MIDA) acylboronates, demonstrated that certain acylboron species can be both remarkably stable and uniquely reactive. Here we report new classes of ligands for acylboronates that have a significant influence on the formation, properties, and reactivities of acylboronates. Our systematic investigations identified a class of neutral, monofluoroboronates that can be prepared in a one step, gram-scale fashion from readily accessible KATs. These monofluoroboronates are stable to air, moisture, and silica gel chromatography and can be easily handled without any special precautions. X-ray crystallography, NMR spectroscopy, and HPLC studies showed that they are tetravalent, configurationally stable B-chiral acylboronates. Significantly, the ligands on the boronate allow for fine-tuning of the properties and reactivity of acylboronates. In amide-forming ligation with hydroxylamines under aqueous conditions, a considerable difference in reactivity was observed as a function of ligand structure. The solid-state structures suggested that subtle steric and conformational factors modulate the reactivities of the acylboronates.

Synthesis in 3 Azafluorene Group. Part-III

Chatterjea, J. N.,Shaw, S. C.,Prasad, Y.,Singh, R. P.

, p. 1028 - 1031 (2007/10/02)

The Hey-Elks route to arylated pyridines has been utilised in the synthesis of 3-azafluorenes.The pyrido-coumarin (23) and the related chromene (24) have been synthesised.

Directing Group-Promoted Inert C?O Bond Activation Using Versatile Boronic Acid as a Coupling Agent

Ambre, Ram,Wang, Ting-Hsuan,Xian, Anmei,Chen, Yu-Shiuan,Liang, Yu-Fu,Jurca, Titel,Zhao, Lili,Ong, Tiow-Gan

supporting information, p. 17021 - 17026 (2020/11/30)

A simple Ni(cod)2 and carbene mediated strategy facilitates the efficient catalytic cross-coupling of methoxyarenes with a variety of organoboron reagents. Directing groups facilitate the activation of inert C?O bonds in under-utilized aryl methyl ethers enabling their adaptation for C?C cross-coupling reactions as less toxic surrogates to the ubiquitous haloarenes. The method reported enables C?C cross-coupling with readily available and economical arylboronic acid reagents, which is unprecedented, and compares well with other organoboron reagents with similarly high reactivity. Extension to directing group assisted chemo-selective C?O bond cleavage, and further application towards the synthesis of novel bifunctionalized biaryls is reported. Key to the success of this protocol is the use of directing groups proximal to the reaction center to facilitate the activation of the inert C?OMe bond.

Copper-catalyzed fluorination of 2-pyridyl aryl bromides

Mu, Xin,Zhang, Hao,Chen, Pinhong,Liu, Guosheng

, p. 275 - 280 (2014/01/06)

Copper(i)-catalyzed cross-coupling of aryl halides is the subject of extensive interest in synthetic chemistry, but the related catalytic fluorination is unsuccessful. Herein, we have developed a novel copper-catalyzed fluorination of aryl bromides using

Process route upstream and downstream products

Process route

methanol
67-56-1

methanol

2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V);Inacetonitrile;at 120 ℃;
80%
2-chloro-4-picoline
3678-62-4

2-chloro-4-picoline

2-Methoxyphenylboronic acid
5720-06-9

2-Methoxyphenylboronic acid

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;Intetrahydrofuran; water;at 90 ℃; for 18h; Inert atmosphere;
84%
2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

2-methoxyphenylmagnesium bromide
16750-63-3

2-methoxyphenylmagnesium bromide

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II);Intetrahydrofuran;
96%
methanol
67-56-1

methanol

2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V);Inacetonitrile;at 120 ℃;
34%
54%
2-Methoxyphenylboronic acid
5720-06-9

2-Methoxyphenylboronic acid

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate;Inethanol; toluene;Heating;
2-methoxy-phenylamine
90-04-0

2-methoxy-phenylamine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: conc. hydrochloric acid, aq. sodium nitrite; sodium carbonate / H2O / 4 °C
2: hydrogen chloride / 100 °C
With hydrogenchloride; sodium carbonate; sodium nitrite;Inwater;
methanol
67-56-1

methanol

2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V);Inacetonitrile;at 120 ℃;
80%
2-chloro-4-picoline
3678-62-4

2-chloro-4-picoline

2-Methoxyphenylboronic acid
5720-06-9

2-Methoxyphenylboronic acid

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;Intetrahydrofuran; water;at 90 ℃; for 18h; Inert atmosphere;
84%
2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

2-methoxyphenylmagnesium bromide
16750-63-3

2-methoxyphenylmagnesium bromide

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II);Intetrahydrofuran;
96%
methanol
67-56-1

methanol

2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
ConditionsYield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V);Inacetonitrile;at 120 ℃;
34%
54%

Global suppliers and manufacturers

Global( 1) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
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  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
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