Welcome to LookChem.com Sign InJoin Free

Cas Database

1000339-35-4

1000339-35-4

Identification

  • Product Name:5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE

  • CAS Number: 1000339-35-4

  • EINECS:

  • Molecular Weight:306.18

  • Molecular Formula:C10H12BrNO3S

  • HS Code:

  • Mol File:1000339-35-4.mol

Synonyms:5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE;5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULPHONAMIDE

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:5-Bromo-N-cyclopropyl-2-methoxybenzenesulfonamide
  • Packaging:1g
  • Price:$ 75
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5-Bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 97%
  • Packaging:5 g
  • Price:$ 368
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:5-Bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 97%
  • Packaging:1 g
  • Price:$ 103
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:5-Bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 95%
  • Packaging:5g
  • Price:$ 778
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:5-Bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 95%
  • Packaging:1g
  • Price:$ 250
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:5-bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 95+%
  • Packaging:25g
  • Price:$ 339
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Crysdot
  • Product Description:5-bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 95+%
  • Packaging:100g
  • Price:$ 923
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:5-bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 95%
  • Packaging:100g
  • Price:$ 870
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:5-bromo-N-cyclopropyl-2-methoxybenzenesulfonamide 95%
  • Packaging:25g
  • Price:$ 320
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Apolloscientific
  • Product Description:5-Bromo-N-cyclopropyl-2-methoxybenzenesulphonamide 97%
  • Packaging:5g
  • Price:$ 334
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 2 Articles be found

Fragment-based discovery of bromodomain inhibitors part 2: Optimization of phenylisoxazole sulfonamides

Bamborough, Paul,Diallo, Hawa,Goodacre, Jonathan D.,Gordon, Laurie,Lewis, Antonia,Seal, Jonathan T.,Wilson, David M.,Woodrow, Michael D.,Chung, Chun-Wa

supporting information; experimental part, p. 587 - 596 (2012/03/26)

Bromodomains are epigenetic reader modules that regulate gene transcription through their recognition of acetyl-lysine modified histone tails. Inhibitors of this protein-protein interaction have the potential to modulate multiple diseases as demonstrated by the profound anti-inflammatory and antiproliferative effects of a recently disclosed class of BET compounds. While these compounds were discovered using phenotypic assays, here we present a highly efficient alternative approach to find new chemical templates, exploiting the abundant structural knowledge that exists for this target class. A phenyl dimethyl isoxazole chemotype resulting from a focused fragment screen has been rapidly optimized through structure-based design, leading to a sulfonamide series showing anti-inflammatory activity in cellular assays. This proof-of-principle experiment demonstrates the tractability of the BET family and bromodomain target class to fragment-based hit discovery and structure-based lead optimization.

1,3,5-TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF

-

Page/Page column 15, (2013/07/05)

The present invention relates to compounds corresponding to formula (I) in which: - R1 represents a substituted phenyl; - R2 represents: - a substituted phenyl; - a heteroaromatic group, the said group being unsubstituted or substituted one or more times; - R3 represents a group Alk; - R4 represents a hydrogen atom or a (C1-C4)alkyl; - R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; - or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; - R6 represents a group -COOAlk, a group -CONH2 or a group -NHSO2 Alk; - Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use

Process route upstream and downstream products

Process route

5-bromo-2-methoxybenzenesulfonyl chloride
23095-05-8

5-bromo-2-methoxybenzenesulfonyl chloride

Cyclopropylamine
765-30-0

Cyclopropylamine

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide
1000339-35-4

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide

Conditions
ConditionsYield
With bis(isopropyl)ethylamine;Indichloromethane;at 20 ℃; Inert atmosphere;
Indichloromethane;at 20 ℃; for 72h;
1.32 g
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide
1000339-35-4

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuryl dichloride / 1 h / 20 °C
2: dichloromethane / 72 h / 20 °C
With sulfuryl dichloride;Indichloromethane;
5-bromo-2-methoxybenzenesulfonyl chloride
23095-05-8

5-bromo-2-methoxybenzenesulfonyl chloride

Cyclopropylamine
765-30-0

Cyclopropylamine

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide
1000339-35-4

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide

Conditions
ConditionsYield
With bis(isopropyl)ethylamine;Indichloromethane;at 20 ℃; Inert atmosphere;
Indichloromethane;at 20 ℃; for 72h;
1.32 g
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide
1000339-35-4

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuryl dichloride / 1 h / 20 °C
2: dichloromethane / 72 h / 20 °C
With sulfuryl dichloride;Indichloromethane;

Global suppliers and manufacturers

Global( 6) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
close

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields

CAS No.:
* Product Name:
* Your email:

Your email will be used to sign-in to LookChem.com
* Requirements:
* Valid for:
 
Post Buying Request Now
close
Remarks: The blank with*must be completed