5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE

Base Information

• Chemical Name: 5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE
• CAS No.: 1000339-35-4
• Molecular Formula: C10H12BrNO3S
• Molecular Weight: 306.18
• Hs Code.: 2935909099
• Mol file: 1000339-35-4.mol

Synonyms:5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE;5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULPHONAMIDE

Chemical Property of 5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE

Chemical Property:

• PSA: 63.78000
• LogP: 3.37010

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-N-cyclopropyl-2-methoxybenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE

There total 2 articles about 5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-methoxybenzenesulfonyl chloride (23095-05-8) + Cyclopropylamine (765-30-0) → 5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide (1000339-35-4)

Guidance literature:

With bis(isopropyl)ethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm201283q

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide (1000339-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / 1 h / 20 °C

2: dichloromethane / 72 h / 20 °C

With sulfuryl dichloride; In dichloromethane;

Reference yield: 64.0%

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole (832114-00-8) + 5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide (1000339-35-4) → N-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-2-(methyloxy)benzenesulfonamide (1355554-26-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.5h;

DOI:10.1021/jm201283q

upstream raw materials:

5-bromo-2-methoxybenzenesulfonyl chloride

Cyclopropylamine

1-bromo-4-methoxy-benzene

Downstream raw materials:

N-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-2-(methyloxy)benzenesulfonamide

N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide

Refernces

• 1、 Bamborough, Paul,Diallo, Hawa,Goodacre, Jonathan D.,Gordon, Laurie,Lewis, Antonia,Seal, Jonathan T.,Wilson, David M.,Woodrow, Michael D.,Chung, Chun-Wa. "Fragment-based discovery of bromodomain inhibitors part 2: Optimization of phenylisoxazole sulfonamides". supporting information; experimental part. p. 587 - 596. Retrieved 2012/03/26.