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Cas Database

1000341-55-8

1000341-55-8

Identification

  • Product Name:6-Chloro-3-iodo-5-azaindole

  • CAS Number: 1000341-55-8

  • EINECS:

  • Molecular Weight:278.48

  • Molecular Formula:C7H4ClIN2

  • HS Code:

  • Mol File:1000341-55-8.mol

Synonyms:6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine, 6-chloro-3-iodo-

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:6-Chloro-3-iodo-5-azaindole
  • Packaging:2mg
  • Price:$ 60
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%+
  • Packaging:1g
  • Price:$ 431
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%+
  • Packaging:250mg
  • Price:$ 181
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%+
  • Packaging:100mg
  • Price:$ 110
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:6-CHLORO-3-IODO-5-AZAINDOLE 95.00%
  • Packaging:5MG
  • Price:$ 500.75
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%
  • Packaging:250mg
  • Price:$ 105
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%
  • Packaging:100mg
  • Price:$ 75
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%
  • Packaging:1g
  • Price:$ 270
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine 95%
  • Packaging:5g
  • Price:$ 956
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine
  • Packaging:5g
  • Price:$ 867.26
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

N-substituted azaindoles as potent inhibitors of Cdc7 kinase

Bryan, Marian C.,Falsey, James R.,Frohn, Mike,Reichelt, Andreas,Yao, Guomin,Bartberger, Michael D.,Bailis, Julie M.,Zalameda, Leeanne,Miguel, Tisha San,Doherty, Elizabeth M.,Allen, John G.

, p. 2056 - 2060 (2013/05/09)

Cdc7 kinase is responsible for the initiation and regulation of DNA replication and has been proposed as a target for cancer therapy. We have identified a class of Cdc7 inhibitors based on a substituted indole core. Synthesis of focused indole and azaindole analogs yielded potent and selective 5-azaindole Cdc7 inhibitors with improved intrinsic metabolic stability (ie 36). In parallel, quantum mechanical conformational analysis helped to rationalize SAR observations, led to a proposal of the preferred binding conformation in the absence of co-crystallography data, and allowed the design of 7-azaindole 37 as a second lead in this series.

AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS

-

Page/Page column 135, (2014/06/11)

This invention relates to novel compounds of formula (I) which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer. (Formula I)

Process route upstream and downstream products

Process route

6-chloro-1H-pyrrolo[3,2-c]pyridine
74976-31-1

6-chloro-1H-pyrrolo[3,2-c]pyridine

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine
1000341-55-8

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine

Conditions
ConditionsYield
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 0.833333h;
93%
With iodine; potassium hydroxide;regiospecific reaction;
87%
6-chloro-1H-pyrrolo[3,2-c]pyridine
74976-31-1

6-chloro-1H-pyrrolo[3,2-c]pyridine

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine
1000341-55-8

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine

Conditions
ConditionsYield
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 0.833333h;
93%
With iodine; potassium hydroxide;regiospecific reaction;
87%

1000341-55-8 Upstream products

Global suppliers and manufacturers

Global( 14) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
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