100056-79-9Relevant articles and documents
Free-Radical Ring Expansion of Fused Cyclobutanones: Stereospecific Construction of 5,7-, 6,7-, 7,7-, 8,7-, and 5,8-Cis-Fused Bicyclic Systems
Dowd, Paul,Zhang, Wei
, p. 7163 - 7171 (2007/10/02)
A new method of appending seven- and eight-membered rings to cycloalkenes is described.Treatment of selected alkene precursors with an ω-bromoalkyl ketene or a keteniminium salt leads to haloalkyl cyclobutanone formation.Tri-n-butyltin hydride promoted ring expansion then yields the annulated product.Since the initial cyclobutanone is cis fused, the final product is also produced stereospecifically with a cis ring fusion.
Regioselective Lewis Acid-mediated α-sec-Alkylation of Carbonyl Compounds
Reetz, Manfred T.,Walz, Peter,Huebner, Friedhelm,Huettenhain, Stefan H.,Heimbach, Horst,Schwellnus, Konrad
, p. 322 - 335 (2007/10/02)
Carbonyl compounds such as ketones, aldehydes, acyloins, or carboxylic esters can be alkylated at the α-position via the corresponding O-silylated forms using activated alkyl halides or acetates in the presence of Lewis acids.In the case of unsymmetricall