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10006-74-3

10006-74-3

Identification

Synonyms:Pyridine,2-amino-3-ethoxy- (7CI,8CI);2-Amino-3-ethoxypyridine;3-Ethoxy-2-aminopyridine;3-Ethoxypyridin-2-amine;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH318 Causes serious eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:TRC
  • Product Description:3-Ethoxy-2-pyridinamine
  • Packaging:50mg
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Amino-3-ethoxypyridine
  • Packaging:1 g
  • Price:$ 280
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Ethoxy-2-pyridinamine >95%
  • Packaging:500mg
  • Price:$ 156
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Ethoxy-2-pyridinamine >95%
  • Packaging:1g
  • Price:$ 240
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:3-Ethoxypyridin-2-amine 95+%
  • Packaging:5g
  • Price:$ 817
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:3-Ethoxy-2-pyridinamine 95%
  • Packaging:5g
  • Price:$ 772
  • Delivery:In stock
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  • Manufacture/Brand:ChemBridge Corporation
  • Product Description:3-ethoxy-2-pyridinamine 95%
  • Packaging:5 g
  • Price:$ 595
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-Amino-3-ethoxypyridine
  • Packaging:500 mg
  • Price:$ 340
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-Amino-3-ethoxypyridine
  • Packaging:1 g
  • Price:$ 595
  • Delivery:In stock
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  • Manufacture/Brand:Biosynth Carbosynth
  • Product Description:2-Amino-3-ethoxypyridine
  • Packaging:250 mg
  • Price:$ 197.5
  • Delivery:In stock
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Relevant articles and documentsAll total 4 Articles be found

BIARYL-CONTAINING COMPOUNDS AS INVERSE AGONISTS OF ROR-GAMMA RECEPTORS

-

Paragraph 00356; 00358, (2014/01/18)

The present invention relates to biaryl-containing inverse agonists of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these biaryl- containing inverse agonists, and methods of modulating ROR-gamma receptors using these inverse agonists. Also provided are methods of using biaryl-containing inverse agonists to treat ROR-gamma mediated diseases.

BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5

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Page/Page column 33-34, (2010/02/11)

The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.

Process route upstream and downstream products

Process route

3-ethoxy-2-nitropyridine
74037-50-6

3-ethoxy-2-nitropyridine

2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

3-amino-2-nitropyridine
13269-19-7

3-amino-2-nitropyridine

Conditions
Conditions Yield
With ammonium hydroxide; at 140 - 150 ℃;
3-ethoxy-2-nitropyridine
74037-50-6

3-ethoxy-2-nitropyridine

2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

Conditions
Conditions Yield
With iron; ammonium chloride; acetic acid; In ethanol; at 80 ℃; for 1h;
65%
With hydrogenchloride; tin(ll) chloride;
With hydrogen; platinum(IV) oxide; In ethanol; at 40 ℃; for 3h;
With hydrogen; palladium on activated charcoal;
2-amino-3-hydroxypyridine
16867-03-1

2-amino-3-hydroxypyridine

sodium hydroxide,and

sodium hydroxide,and

hexane
110-54-3

hexane

2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

Conditions
Conditions Yield
With sodium hydrogencarbonate; In methanol; water; dimethyl sulfoxide;
3-hydroxy-2-nitropyridine
15128-82-2

3-hydroxy-2-nitropyridine

2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C
2: ammonium chloride; acetic acid; iron / ethanol / 1 h / 80 °C
With iron; potassium carbonate; ammonium chloride; acetic acid; In ethanol; N,N-dimethyl-formamide;
3-ethoxypyridine
14773-50-3

3-ethoxypyridine

2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: concentrated sulfuric acid; fuming nitric acid / -15 °C / und folgenden 1-stdg.Erwaermen auf dem Wasserbad
2: tin (II)-chloride; concentrated hydrochloric acid
With hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride;
2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

Conditions
Conditions Yield
2-Brom-3-ethoxypyridin, KNH2 (fl. NH3);
2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

2-amino-3-hydroxypyridine
16867-03-1

2-amino-3-hydroxypyridine

Conditions
Conditions Yield
With acetic acid hydrobromide; at 130 ℃;
2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

5-fluoro-2-(3-methylsulphanyl-phenoxy)-nicotinic acid
832099-55-5

5-fluoro-2-(3-methylsulphanyl-phenoxy)-nicotinic acid

N-(3-ethoxy-pyridin-2-yl)-5-fluoro-2-(3-methylsulfanyl-phenoxy)-nicotinamide

N-(3-ethoxy-pyridin-2-yl)-5-fluoro-2-(3-methylsulfanyl-phenoxy)-nicotinamide

Conditions
Conditions Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;
2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

sulfanilic acid-(3-ethoxy-[2]pyridylamide)
71119-19-2

sulfanilic acid-(3-ethoxy-[2]pyridylamide)

Conditions
Conditions Yield
With pyridine; Erwaermen des Reaktionsproduktes mit Eisen-Pulver in wenig wss. HCl enthaltendem Aethanol;
2-Amino-3-(ethoxy)pyridine
10006-74-3

2-Amino-3-(ethoxy)pyridine

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

<i>N</i>-hydroxy-sulfanilic acid-(3-ethoxy-[2]pyridylamide)

N-hydroxy-sulfanilic acid-(3-ethoxy-[2]pyridylamide)

Conditions
Conditions Yield
With pyridine; Hydrieren des Reaktionsproduktes an Palladium/CaCO3 in Aethanol bei 50grad;

Global suppliers and manufacturers

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  • SAGECHEM LIMITED
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  • Amadis Chemical Co., Ltd.
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  • Capot Chemical Co., Ltd.
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  • PRIME MOLECULAR CO.,LIMITED
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  • Contact Tel:0852-0755-61104662
  • Emails:sales@prime-molecular.com
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  • Tianjin SPHINX SCIENTIFIC LAB.
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