100074-40-6

Basic information

• Product Name: phenylacetic acid
• Synonyms: phenylacetic acid
• CAS NO: 100074-40-6
• Molecular Weight: 236.268
• Mol File: 100074-40-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: phenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: phenylacetic acid(100074-40-6)
• EPA Substance Registry System: phenylacetic acid(100074-40-6)

Safety Data

• Hazardous Substances Data: 100074-40-6(Hazardous Substances Data)

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 99-94-5 p-Toluic acid 
• 622-47-9 4-tolylacetic acid 
• 105-36-2 ethyl bromoacetate 
• 25307-01-1 p-tolylacetic acid sodium salt 

Downstream Products

• 1421237-15-1 C₂₃H₂₄FNO₅ 
• 1504595-20-3 C₁₃H₁₃BrO₃ 
• 1514777-75-3 7-(4-(2-(3-(4-methylphenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1514777-73-1 7-(4-(2-(3-(4-methylphenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 100074-66-6 4-methoxy-3-(4-methylphenyl)-5H-furan-2-one 
• 100074-53-1 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one 

Relevant articles and documents

Compound, as well as preparation method and application thereof

The application discloses a compound of which the structure is represented as the following formula, wherein R1 is selected from any one of F, Cl, Br, C1-C5 alkyl group, and a group having the structure as the formula (1), n = 0, 1, 2, 3, 4 or 5; the R2 is selected from any one of a group having the structure as the formula (1), a group having the structure as the formula (2), and a group having the structure as the formula (3). The compound has simple preparation method, can be used as a neuraminidase inhibitor, and has excellent antivirus activity.

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

3-Arylfuran-2(5H)-one, a novel antibacterial pharmacophore targeting tyrosyl-tRNA synthetase (TyrRS), was hybridized with the clinically used fluoroquinolones to give a series of novel multi-target antimicrobial agents. Thus, twenty seven 3-arylfuran-2(5H)-one-fluoroquinolone hybrids were synthesized and evaluated for their antimicrobial activities. Some of the hybrids exhibited merits from both parents, displaying a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive bacteria. The most potent compound (11) in antibacterial assay shows MIC50 of 0.11 μg/mL against Multiple drug resistant Escherichia coli, being about 51-fold more potent than ciprofloxacin. The enzyme assays reveal that 11 is a potent multi-target inhibitor with IC50 of 1.15 ± 0.07 μM against DNA gyrase and 0.12 ± 0.04 μM against TyrRS, respectively. Its excellent inhibitory activities against isolated enzymes and intact cells strongly suggest that 11 deserves to further research as a novel antibiotic.

Synthesis of (E)- and (Z)-Pulvinones

Two new routes to pulvinones have been developed, one of which involves a novel Wittig reaction.For the first time, members of the E-series, including the parent (E)-pulvinone, are reported and the structural elucidation of the geometric isomers is descri