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Ethylbromoacetate Manufacturer/High quality/Best price/In stock
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ethyl bromoacetate
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Ethyl bromoacetate
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High Quality Ethyl Bromoacetate
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Amadis Chemical offer CAS#105-36-2;CAT#A801205
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Ethyl bromoacetate
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Ethyl bromoacetate CAS: 105-36-2
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105-36-2 Usage

Reactivity Profile

Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Uses

Ethyl Bromoacetate, is used in the synthesis of metabolites of carcinogenic PAHs. Used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.

Safety Profile

A poison. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid when exposed to heat, flame, and oxidizers. Will react with water or steam to produce toxic and corrosive fumes. To fight fire, use water as a fire blanket. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of Br-. See also BROMIDES.

General Description

A clear, colorless liquid (b.p. 318°F). Flash point 47°C. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.

Hazard

Toxic by ingestion, inhalation, and skin absorption; strong irritant.

Purification Methods

Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.

Potential Exposure

Used for making pharmaceuticals; as a warning gas in poisonous, odorless gasses; as a tear gas

Chemical Properties

Ethyl bromoacetate is a clear, colorless to light-yellow liquid and has a pungent odor. It is insoluble in water, but is soluble in acetone and benzene (Lide, 1999; Lewis, 1997). Ethyl bromoacetate is miscible with ethanol, ethyl ether, and with other oxygenated and aromatic solvents (Ashford, 1994; Lide, 1999). It is partially decomposed by water (Lewis, 1997).

Incompatibilities

Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Shipping

UN1603 Ethyl bromoacetate, Hazard class: 6.1; Labels: 6.1-Poisonous materials.

Air & Water Reactions

Flammable. Insoluble in water.
InChI:InChI=1/C4H7BrO2/c1-2-3(5)4(6)7/h3H,2H2,1H3,(H,6,7)/p-1

105-36-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (B0532)  Ethyl Bromoacetate  >98.0%(GC) 105-36-2 25g 160.00CNY Detail
TCI America (B0532)  Ethyl Bromoacetate  >98.0%(GC) 105-36-2 500g 710.00CNY Detail
Alfa Aesar (A10448)  Ethyl bromoacetate, 98%    105-36-2 100g 205.0CNY Detail
Alfa Aesar (A10448)  Ethyl bromoacetate, 98%    105-36-2 500g 647.0CNY Detail
Alfa Aesar (A10448)  Ethyl bromoacetate, 98%    105-36-2 2500g 2342.0CNY Detail

105-36-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl bromoacetate

1.2 Other means of identification

Product number -
Other names ETHYL BROMOACETATE/BROMOACETIC ACID ETHYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105-36-2 SDS

105-36-2Synthetic route

ethanol
64-17-5

ethanol

acetic acid
64-19-7

acetic acid

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With bromine; phosphorus tribromide for 0.5h; Hell-Volhard-Zelinsky reaction; Heating;100%
With phosphorus tribromide 1.) r.t., 5 min; reflux, 3 h, 2.) r.t., overnight; Yield given. Multistep reaction;
ethanol
64-17-5

ethanol

bromoacetic acid
79-08-3

bromoacetic acid

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With thionyl chloride In diethyl ether at 0 - 20℃;95%
With sulfuric acid for 24h; Reflux;85%
at 100℃;
C10H25N3O2PS(1+)
103514-71-2

C10H25N3O2PS(1+)

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With bromide In N,N-dimethyl-formamide95%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With 1-bromo-butane; [HB(3,5-(CF3)2Pz)3]Ag(THF)78%
With chloroform; hydrogen bromide
ethyl vinyl ether
109-92-2

ethyl vinyl ether

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With tetraethylammonium bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dichloromethane at 20℃; for 0.166667h; regioselective reaction;65%
ethanol
64-17-5

ethanol

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
Stage #1: ethanol With triethylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: 2-Bromoacetyl bromide In dichloromethane at 0 - 25℃; for 5h;
42%
diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium
227945-00-8

diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium

A

diethyl 2-amino-6-[(2-oxo-2-ethoxy-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate

diethyl 2-amino-6-[(2-oxo-2-ethoxy-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate

B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
A 24%
B n/a
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

(+)-(S)-isopropyl-p-toluenesulphinamide
6873-86-5, 111289-37-3, 116560-14-6

(+)-(S)-isopropyl-p-toluenesulphinamide

A

ethyl bromoacetate
105-36-2

ethyl bromoacetate

B

/PBBPD039-1840/

/PBBPD039-1840/

Conditions
ConditionsYield
With n-butyllithium Product distribution; 1.) THF, -30 deg C, 15 min, 2.) THF, 0 deg C, 5 h; further temperatures; further alkylating agents; regio and stereochemistry of alkylation;A 3%
B n/a
bromoacetic anhydride
13094-51-4

bromoacetic anhydride

ethanol
64-17-5

ethanol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

ethyl bromide
74-96-4

ethyl bromide

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
bei der Einwirkung von UV-Licht;
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

t-butyl bromide
507-19-7

t-butyl bromide

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
Photolysis;
ethyl bromide
74-96-4

ethyl bromide

thiocyanato-acetic acid ethyl ester
5349-28-0

thiocyanato-acetic acid ethyl ester

A

ethyl isothiocyanate
542-90-5

ethyl isothiocyanate

B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
at 120℃;
2-bromoacetyl chloride
22118-09-8

2-bromoacetyl chloride

ethanol
64-17-5

ethanol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diethyl ether
60-29-7

diethyl ether

bromocyane
506-68-3

bromocyane

ethyl N,N-diethylglycinate
2644-21-5

ethyl N,N-diethylglycinate

A

N-ethyl-N-cyano-glycine ethyl ester

N-ethyl-N-cyano-glycine ethyl ester

B

Diethylcyanamide
617-83-4

Diethylcyanamide

C

ethyl bromoacetate
105-36-2

ethyl bromoacetate

bromocyane
506-68-3

bromocyane

ethyl N,N-diethylglycinate
2644-21-5

ethyl N,N-diethylglycinate

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Acetyl bromide
506-96-7

Acetyl bromide

ethyl 2-ethoxyethanoate
817-95-8

ethyl 2-ethoxyethanoate

A

ethyl bromide
74-96-4

ethyl bromide

B

acetoxy-acetic acid ethyl ester
623-86-9

acetoxy-acetic acid ethyl ester

C

ethyl acetate
141-78-6

ethyl acetate

D

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
at 190℃;
vinylidene dibromide
593-92-0

vinylidene dibromide

ethanol
64-17-5

ethanol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

1-ethoxy-1,2-dibromo-ethene
24298-33-7

1-ethoxy-1,2-dibromo-ethene

A

ethyl bromide
74-96-4

ethyl bromide

B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With ethanol
ethanol
64-17-5

ethanol

bromo-acetic acid-(1-bromo-ethyl ester)
861797-08-2

bromo-acetic acid-(1-bromo-ethyl ester)

A

diethyl acetal
105-57-7

diethyl acetal

B

ethyl bromide
74-96-4

ethyl bromide

C

ethyl bromoacetate
105-36-2

ethyl bromoacetate

D

crotonaldehyde
123-73-9

crotonaldehyde

ethanol
64-17-5

ethanol

2,2,3,4-tetrabromo-butyraldehyde

2,2,3,4-tetrabromo-butyraldehyde

A

ethyl bromide
74-96-4

ethyl bromide

B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

C

Bromoacetaldehyde diethyl acetal
2032-35-1

Bromoacetaldehyde diethyl acetal

D

bromoacetaldehyde
17157-48-1

bromoacetaldehyde

1,1,2,2-tetrabromoethene
79-28-7

1,1,2,2-tetrabromoethene

sodium ethanolate
141-52-6

sodium ethanolate

A

3,4-dibromobut-3-en-2-ol
70442-46-5

3,4-dibromobut-3-en-2-ol

B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With phosphorus pentabromide
With phosphorus tribromide In dichloromethane for 0.5h; Cooling with ice;
acetic anhydride
108-24-7

acetic anhydride

acetic acid
64-19-7

acetic acid

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With pyridine; bromine durch folgende Veresterung mit Aethanol in Gegenwart von konz. H2SO4 in siedendem Benzol;
antimony (V)-triethylate dibromide

antimony (V)-triethylate dibromide

A

ethyl bromide
74-96-4

ethyl bromide

B

diethyl ether
60-29-7

diethyl ether

C

ethanol
64-17-5

ethanol

D

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
at 130 - 135℃;
acetic acid
64-19-7

acetic acid

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With phosphorus; bromine Abdestillieren des ueberschuessigen Broms und Giessen des Reaktionsprodukts in Alkohol;
With bromine; acetic anhydride at 100℃; und Behandlung des Reaktionsprodukts mit Alkohol auf dem Wasserbad;
acetyl chloride
75-36-5

acetyl chloride

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Conditions
ConditionsYield
With phosphorus; bromine bei der Einw. von absol. Aethanol auf das Reaktionsgemisch;
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

A

ethyl bromoacetate
105-36-2

ethyl bromoacetate

B

Ethyl 2-bromo-3-methyl-4-pentenoate
79357-22-5

Ethyl 2-bromo-3-methyl-4-pentenoate

Ethyl 2-(bromomethyl)-3-methylcyclopropanecarboxylate
79357-25-8

Ethyl 2-(bromomethyl)-3-methylcyclopropanecarboxylate

Ethyl 2-(bromomethyl)-3-methylcyclopropanecarboxylate
79390-68-4

Ethyl 2-(bromomethyl)-3-methylcyclopropanecarboxylate

Conditions
ConditionsYield
dirhodium tetraacetate at 4℃; Yield given. Yields of byproduct given;
ethyl 2-(tributylstannyl)acetate
681-94-7

ethyl 2-(tributylstannyl)acetate

acetophenone
98-86-2

acetophenone

A

ethyl acetate
141-78-6

ethyl acetate

B

ethyl bromoacetate
105-36-2

ethyl bromoacetate

C

α-bromoacetophenone
70-11-1

α-bromoacetophenone

Conditions
ConditionsYield
With tributyltin iodide; bromine Product distribution; 1.) DMSO, 75 deg C, 36 h;A 82 % Chromat.
B 10 % Chromat.
C 75 % Chromat.
1,2-dibromo-1-fluoro-ethene
358-98-5

1,2-dibromo-1-fluoro-ethene

sodium ethanolate
141-52-6

sodium ethanolate

A

ethyl bromoacetate
105-36-2

ethyl bromoacetate

B

(E)-1,2-Dibromo-1-ethoxy-ethene

(E)-1,2-Dibromo-1-ethoxy-ethene

C

(E)-2-Bromo-1-ethoxy-1-fluoro-ethene

(E)-2-Bromo-1-ethoxy-1-fluoro-ethene

D

(Z)-2-Bromo-1-ethoxy-1-fluoro-ethene

(Z)-2-Bromo-1-ethoxy-1-fluoro-ethene

Conditions
ConditionsYield
In ethanol Further byproducts given. Yields of byproduct given;A 7 % Spectr.
B 20 % Spectr.
C n/a
D n/a
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

chloroform
67-66-3

chloroform

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

ethyl bromoacetate
105-36-2

ethyl bromoacetate

morpholine
110-91-8

morpholine

ethyl bromoacetate
105-36-2

ethyl bromoacetate

N-morpholylacetic acid ethyl ester
3235-82-3

N-morpholylacetic acid ethyl ester

Conditions
ConditionsYield
In benzene for 0.5h; Reflux;100%
In toluene for 8h;92%
In benzene for 0.5h; Alkylation; Heating;91%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-(4-formylphenoxy)acetate
51264-69-8

ethyl 2-(4-formylphenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;100%
Stage #1: 4-hydroxy-benzaldehyde With potassium carbonate; sodium iodide In acetonitrile for 0.5h; Heating;
Stage #2: ethyl bromoacetate In acetonitrile for 18h; Heating;
98%
With potassium carbonate In acetone at 20℃; for 2h;95%
vanillin
121-33-5

vanillin

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-(4-formyl-2-methoxyphenoxy)acetate
51264-70-1

ethyl 2-(4-formyl-2-methoxyphenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone for 14h; Reflux; Inert atmosphere;100%
With potassium carbonate In acetone for 4h; Reflux; Inert atmosphere;98%
With potassium carbonate In acetone for 14h; Reflux;96%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

phenyl isopropyl ketone
611-70-1

phenyl isopropyl ketone

(+/-)-Ethyl 3-hydroxy-4-methyl-3-phenylpentanoate
92301-37-6

(+/-)-Ethyl 3-hydroxy-4-methyl-3-phenylpentanoate

Conditions
ConditionsYield
With iodine; zinc In 1,4-dioxane for 0.583333h; Reformatsky reaction; ultrasound irradiation;100%
86%
With zinc; benzene
ethyl bromoacetate
105-36-2

ethyl bromoacetate

triethyl phosphite
122-52-1

triethyl phosphite

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

Conditions
ConditionsYield
at 60 - 80℃; for 0.5h; Arbusov reaction;100%
at 150℃; for 3h;99%
for 0.0333333h; Michaelis-Arbuzov reaction; microwave irradiation;98%
1,1,3,3-tetramethyl-2-thiourea
2782-91-4

1,1,3,3-tetramethyl-2-thiourea

ethyl bromoacetate
105-36-2

ethyl bromoacetate

2-(2-ethoxy-2-oxoethyl)-1,1,3,3-tetramethylthiouronium bromide

2-(2-ethoxy-2-oxoethyl)-1,1,3,3-tetramethylthiouronium bromide

Conditions
ConditionsYield
at 20℃; for 12h;100%
In acetone
ethyl bromoacetate
105-36-2

ethyl bromoacetate

Cyclopropylamine
765-30-0

Cyclopropylamine

[(cyclopropyl)amino]acetic acid ethyl ester
71922-62-8

[(cyclopropyl)amino]acetic acid ethyl ester

Conditions
ConditionsYield
In ethanol for 1h;100%
With triethylamine In diethyl ether at 20℃;100%
In ethanol at 0 - 20℃; for 18h;99%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl-2-azidoacetate
637-81-0

ethyl-2-azidoacetate

Conditions
ConditionsYield
With sodium azide In water; acetone at 20℃; for 0.5h;100%
With sodium azide In water; acetone at 20℃; for 24h;100%
With sodium azide In water; acetone at 0 - 63℃; for 4h;100%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-nitrooxyacetate
999-17-7

ethyl 2-nitrooxyacetate

Conditions
ConditionsYield
With silver nitrate In acetonitrile at 20℃; for 12h;100%
With trinitromethane; silver(l) oxide In acetonitrile
furfural
98-01-1

furfural

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (E)-3-(2-furyl)prop-2-enoate
623-20-1

ethyl (E)-3-(2-furyl)prop-2-enoate

Conditions
ConditionsYield
With triphenyl phosphite; potassium carbonate; (BrBu2Te)2O In toluene at 80℃; for 42h; Wittig-type olefination;100%
With lithium hydroxide; triphenylphosphine; lithium chloride In water Wittig reaction; Heating;99%
With lithium hydroxide; triphenylphosphine; lithium chloride In water for 0.25h; Wittig reaction; Heating;97%
Indole-3-carboxaldehyde
487-89-8

Indole-3-carboxaldehyde

ethyl bromoacetate
105-36-2

ethyl bromoacetate

(3-formylindol-1-yl)acetic acid ethyl ester
27065-94-7

(3-formylindol-1-yl)acetic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 15 - 20℃; for 16.5h;100%
Stage #1: Indole-3-carboxaldehyde With sodium hydride In N,N-dimethyl-formamide
Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide at 20℃; for 16h;
100%
With sodium hydride In DMF (N,N-dimethyl-formamide) at 15 - 20℃; for 16.5h;100%
indole-2,3-dione
91-56-5

indole-2,3-dione

ethyl bromoacetate
105-36-2

ethyl bromoacetate

(1-ethoxycarbonylmethyl)isatin
41042-21-1

(1-ethoxycarbonylmethyl)isatin

Conditions
ConditionsYield
Stage #1: indole-2,3-dione With calcium hydride In N,N-dimethyl-formamide at 100℃; for 1h;
Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide at 100℃; for 4h;
100%
Stage #1: indole-2,3-dione With aluminum oxide; potassium fluoride In acetonitrile for 0.0833333h;
Stage #2: ethyl bromoacetate In acetonitrile for 21h; Reflux;
97%
With KF-Celite In 2-methyltetrahydrofuran for 4h; Reflux; chemoselective reaction;93%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (E)-3-(4-chlorophenyl)prop-2-enoate
24393-52-0

ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

Conditions
ConditionsYield
With triphenyl phosphite; poly(ethylene glycol) di(2-(n-butyltelluro)ethyl) ether; potassium carbonate In toluene at 80℃;100%
Stage #1: ethyl bromoacetate With triphenyl phosphite; PEG-Te-Bu In toluene at 80℃; for 0.166667h;
Stage #2: With potassium carbonate In toluene for 0.0166667h;
Stage #3: 4-chlorobenzaldehyde In toluene for 7h; Wittig-type olefination; Further stages.;
98%
With N1,N3,N5-tris(4-(diphenylarsino)phenyl)benzene-1,3,5-tricarboxamide; potassium carbonate In neat (no solvent) at 80℃; for 0.5h; Wittig Olefination; stereoselective reaction;96%
4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl (E)-3-(4-nitrophenyl)-2-propenoate
24393-61-1

ethyl (E)-3-(4-nitrophenyl)-2-propenoate

Conditions
ConditionsYield
With polyethyleneimine supported triphenylphosphine In chloroform at 65℃; Wittig Olefination; Inert atmosphere;100%
With Rasta resin-PPh3-NBniPr2 In dichloromethane at 20℃; for 19h; Wittig reaction; Molecular sieve; optical yield given as %de;99%
With triphenylphosphine; nanocrystalline aerogel prepared MgO In N,N-dimethyl-formamide at 20℃; for 3h; Wittig reaction;98%
ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diethyl 2-benzoylsuccinate
10539-50-1

diethyl 2-benzoylsuccinate

Conditions
ConditionsYield
With sodium ethanolate In ethanol cooling;100%
With potassium carbonate; sodium iodide at 65℃; for 2h;63%
With sodium hydride 1.) THF, RT, 2.) THF, RT, 1 h; Yield given. Multistep reaction;
With potassium carbonate In acetone for 20h; Reflux;
benzaldehyde
100-52-7

benzaldehyde

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl cinnamate
4192-77-2

ethyl cinnamate

Conditions
ConditionsYield
With triphenyl phosphite; potassium carbonate; (BrBu2Te)2O In toluene at 80℃; for 36h; Wittig-type olefination;100%
Stage #1: ethyl bromoacetate With triphenyl phosphite; PEG-Te-Bu In toluene at 80℃; for 0.166667h;
Stage #2: With potassium carbonate In toluene for 0.0166667h;
Stage #3: benzaldehyde In toluene for 18h; Further stages.;
98%
With triphenyl phosphite; poly(ethylene glycol) di(2-(n-butyltelluro)ethyl) ether; potassium carbonate In toluene at 80℃;98%
benzene-1,2-diol
120-80-9

benzene-1,2-diol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-<2-<(ethoxycarbonyl)methoxy>phenoxy>acetate
52376-09-7

ethyl 2-<2-<(ethoxycarbonyl)methoxy>phenoxy>acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 120h;100%
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 8h; Heating;95%
With potassium carbonate In N,N-dimethyl-formamide at 75 - 80℃; for 1.5h;90%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

ethyl bromoacetate
105-36-2

ethyl bromoacetate

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate
98269-30-8

diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 16h;100%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 18h;100%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 16h;100%
5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene
157432-87-6, 288302-11-4, 288302-12-5

5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

ethyl bromoacetate
105-36-2

ethyl bromoacetate

5,11,17,23-tetra-tert-butyl-[25,26,27,28-(ethylethanoate)oxy]-calix[4]arene
121702-03-2, 133576-87-1, 97600-39-0, 145511-82-6, 145511-83-7

5,11,17,23-tetra-tert-butyl-[25,26,27,28-(ethylethanoate)oxy]-calix[4]arene

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;100%
With caesium carbonate In acetone at 56℃; for 1h;100%
With potassium carbonate In acetone for 120h; Heating;88%
p-(tert-butyl)hexahomotrioxacalix[3]arene
76543-12-9

p-(tert-butyl)hexahomotrioxacalix[3]arene

ethyl bromoacetate
105-36-2

ethyl bromoacetate

7,15,23-tri-tert-butyl-25,26,27-tris(ethoxycarbonylmethoxy)-2,3,10,11,18,19-hexahomo-3,11,19-trioxacalix[3]arene
151782-37-5, 151852-34-5, 118859-91-9

7,15,23-tri-tert-butyl-25,26,27-tris(ethoxycarbonylmethoxy)-2,3,10,11,18,19-hexahomo-3,11,19-trioxacalix[3]arene

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃; for 6h;100%
With sodium hydride In tetrahydrofuran at 67℃; distribution of cone and partial-cone conformers; other bases, solvents, temperatures and reaction times;
With potassium carbonate In acetone for 12h; Heating;
1-methyl-4-(2-hydroxy-3-methoxyphenyl)-3-(3-oxo-3-ethoxypropyl)pyridinuim iodide
87307-95-7

1-methyl-4-(2-hydroxy-3-methoxyphenyl)-3-(3-oxo-3-ethoxypropyl)pyridinuim iodide

ethyl bromoacetate
105-36-2

ethyl bromoacetate

4-<2-(2-ethoxy-2-oxoethoxy)3-3-methoxyphenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide
87307-96-8

4-<2-(2-ethoxy-2-oxoethoxy)3-3-methoxyphenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 1h;100%
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 1h;
ethyl bromoacetate
105-36-2

ethyl bromoacetate

thiophenol
108-98-5

thiophenol

ethyl phenylsulfenylacetate
7605-25-6

ethyl phenylsulfenylacetate

Conditions
ConditionsYield
With pyridine In ethanol for 2h; Ambient temperature;100%
With triethylamine In tetrahydrofuran at 20℃; for 4h;99%
With 1-pentyl-3-methylimidazolium bromide at 25 - 30℃; for 0.166667h;98%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

ethyl 2-(benzo[d]thiazol-2-ylthio)acetate
24044-88-0

ethyl 2-(benzo[d]thiazol-2-ylthio)acetate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With potassium carbonate In acetone for 3h; Heating;95%
With potassium carbonate In acetonitrile at 20℃; for 3h; Inert atmosphere;74%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

(1aS,3aS,4R,8aR)-1a,4-Dimethyl-octahydro-1-oxa-cyclopropa[c]azulen-8-one
75930-92-6, 75948-26-4

(1aS,3aS,4R,8aR)-1a,4-Dimethyl-octahydro-1-oxa-cyclopropa[c]azulen-8-one

((1aR,3aR,4S,7R,8aS)-1a,4-Dimethyl-8-oxo-octahydro-1-oxa-cyclopropa[c]azulen-7-yl)-acetic acid ethyl ester
75930-94-8

((1aR,3aR,4S,7R,8aS)-1a,4-Dimethyl-8-oxo-octahydro-1-oxa-cyclopropa[c]azulen-7-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine In tetrahydrofuran100%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

2-((isopropylamino)methylene)malononitrile
145162-27-2

2-((isopropylamino)methylene)malononitrile

3-amino-4-cyan-1-(2-propyl)-pyrrol-2-carbonsaeureethylester
145162-35-2

3-amino-4-cyan-1-(2-propyl)-pyrrol-2-carbonsaeureethylester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 5h;100%
With sodium ethanolate; potassium carbonate 1.) DMF, 80 deg C, 30 min, 2.) DMF, ethanol, 60 deg C, 30 min; Yield given. Multistep reaction;
ethyl bromoacetate
105-36-2

ethyl bromoacetate

triphenylphosphine
603-35-0

triphenylphosphine

(carbethoxymethyl)triphenylphosphonium bromide
1530-45-6

(carbethoxymethyl)triphenylphosphonium bromide

Conditions
ConditionsYield
In xylene for 0.00833333h; Heating; microwave irradiation;100%
In ethyl acetate Reflux;100%
In benzene at 20℃;100%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

triethyl propane-1,2,2-tricarboxylate
39994-45-1

triethyl propane-1,2,2-tricarboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature;100%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

2-<(4'-hydroxyphenyl)methyl>-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran
102612-39-5

2-<(4'-hydroxyphenyl)methyl>-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran

2-<<4'-(carbethoxymethoxy)phenyl>methyl>-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran
102612-26-0

2-<<4'-(carbethoxymethoxy)phenyl>methyl>-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran

Conditions
ConditionsYield
With potassium carbonate In acetone for 0.5h; Heating;100%
With potassium carbonate In hexane; acetone
ethyl bromoacetate
105-36-2

ethyl bromoacetate

3,5-dihydroxybenzoic acid benzyl ester
101508-94-5

3,5-dihydroxybenzoic acid benzyl ester

benzyl 3,5-bis(ethoxycarbonylmethoxy)benzoate
153444-36-1

benzyl 3,5-bis(ethoxycarbonylmethoxy)benzoate

Conditions
ConditionsYield
With potassium carbonate In acetone for 4.5h; Heating;100%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

tert-butyl ((trans)-7-methyl-2-oxoazepan-3-yl)carbamate
156557-47-0

tert-butyl ((trans)-7-methyl-2-oxoazepan-3-yl)carbamate

((3S,7S)-3-tert-Butoxycarbonylamino-7-methyl-2-oxo-azepan-1-yl)-acetic acid ethyl ester
156479-94-6

((3S,7S)-3-tert-Butoxycarbonylamino-7-methyl-2-oxo-azepan-1-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran for 0.5h; Ambient temperature;100%

105-36-2Upstream product

105-36-2Downstream Products

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