100101-50-6Relevant articles and documents
Chiral syntheses of 6′-β-fluoroaristeromycin, 6′-β-fluoro-5′-noraristeromycin and aristeromycin
Yin, Xue-Qiang,Schneller, Stewart W.
, p. 7535 - 7538 (2007/10/03)
Carbocyclic nucleosides substituted at the C-6′ position are receiving increasing attention. Chiral synthetic accessibility to the biologically promising 6′-β-fluoroaristeromycin is lacking. Its preparation and that of the 5′-nor analogue are described. A
Enzyme-Catalysed Hydrolyses of Some Meso-Diesters
Cotterill, Ian C.,Cox, Philip B.,Drake, Alex F.,Grand, Darren M. Le,Hutchinson, Edward J.,et al.
, p. 3071 - 3076 (2007/10/02)
The diester 7 is hydrolysed, using porcine pancreatic lipase as catalyst, to give the monoester 8.The latter compound has been converted into the known azido alcohol 9 and into the purine derivative 10.Pig liver esterase (ple) catalysed hydrolysis of the diester 11 gave the acid 13 not the enantiomer 12 as previously reported.The structure of 13 was determined by its conversion into the compound ent-10.The diesters 17 and 18 are converted into the mono-esters 20 and 21 respectively using ple: hydrolysis of the diester 16 yields a mono-acid of high optical purity.The structure of this mono-acid is believed to be that shown in formula 19.
Purinyl or pyrimidinyl substituted hydroxycyclopentane compounds useful as antivirals
-
, (2008/06/13)
Novel 4-substituted-5-hydroxymethyl-1,2-cyclopentanediols or 1-cyclopentanol substituted at the 3-position by various heterocyclic groups are useful as antiviral agents.
