39939-07-6Relevant articles and documents
PCSK9 INHIBITORS AND METHODS OF USE THEREOF
-
Page/Page column 145-146, (2020/07/31)
The invention relates to novel heteroaryl compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cardiovascular diseases, and methods treating sepsis or septic shock, using the novel heterocyclic compounds disclosed herein.
Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction
Llona-Minguez, Sabin,Throup, Adam,Steiner, Emilie,Lightowler, Molly,Van Der Haegen, Sandra,Homan, Evert,Eriksson, Lars,Stenmark, P?l,Jenmalm-Jensen, Annika,Helleday, Thomas
supporting information, p. 7758 - 7764 (2017/10/06)
Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between drug-like molecules and natural products.
Cis,cis,cis,cis-1,2,3,4,5-Pentakis(hydroxymethyl)cyclopentane
Pujol, Adeline R.,Ratel-Ramond, Nicolas,Gourdon, André
, p. 9139 - 9144 (2013/09/24)
All-cis pentamethanolcyclopentane has been obtained in six steps by Diels-Alder condensation of maleic anhydride with (benzyloxymethyl)cyclopenta-2, 4-diene, reduction of the anhydride to a diol that was protected as the acetonide. Then, ozonolysis of the double bond, followed by reduction led to a cis-diol. Then successive deprotections of the three other methanol groups gave the cis,cis,cis,cis-1,2,3,4,5-pentakis(hydroxymethyl)cyclopentane.